Inventors:
Clifton A. Baile - Athens GA, US
Mary Anne Della-Fera - La Veta CO, US
Hea Jin Park - Tolland CT, US
Srujana Rayalam - Athens GA, US
International Classification:
A61K 31/12, A61P 3/00, A61P 19/00, A61K 31/57, A61K 31/352
Abstract:
The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.