MARTYN KERRY DARBY
Pilots at Hogan Rdg Ct, Chapel Hill, NC
License number
North Carolina A5075472
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
104 Hogan Ridge Ct, Chapel Hill, NC 27516
Professional information
Compositions And Methods For Delivery Of Glycopeptide Antibiotics To Medical Device Surfaces
US Patent:
2011003, Feb 17, 2011
Filed:
Oct 17, 2008
Appl. No.:
12/739353
Inventors:
Martyn K. Darby - Chapel Hill NC, US
Isaac G. Sanford - Durham NC, US
R. Edward Benson - Durham NC, US
Hanne Gron - Durham NC, US
Paul T. Hamilton - Cary NC, US
Shrikumar A. Nair - Cary NC, US
Doug Buechter - Chester Springs PA, US
Elliott Gruskin - Malvern PA, US
Isaac G. Sanford - Durham NC, US
R. Edward Benson - Durham NC, US
Hanne Gron - Durham NC, US
Paul T. Hamilton - Cary NC, US
Shrikumar A. Nair - Cary NC, US
Doug Buechter - Chester Springs PA, US
Elliott Gruskin - Malvern PA, US
Assignee:
Affinergy Inc. - Durham NC
Synthes USA, LLC - West Chester PA
Synthes USA, LLC - West Chester PA
International Classification:
A61F 2/02, A61K 38/14, A61K 38/16, A61K 9/00, C07K 19/00, C07K 7/08, C07K 14/00, C07H 21/00, C12N 15/63, A61F 2/32, A61F 2/30, A61F 2/08, A61P 31/00
US Classification:
424423, 514 23, 424400, 530324, 530326, 530327, 530325, 536 231, 4353201
Abstract:
The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
Methods And Compositions For Soft Tissue Repair
US Patent:
2011022, Sep 15, 2011
Filed:
May 17, 2011
Appl. No.:
13/109802
Inventors:
Isaac Gilliam Sanford - Durham NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Yuchen Chen - Chapel Hill NC, US
Ganesan Sathya - Cary NC, US
Hanne Gron - Durham NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Yuchen Chen - Chapel Hill NC, US
Ganesan Sathya - Cary NC, US
Hanne Gron - Durham NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Assignee:
AFFINERGY, INC. - Research Triangle Park NC
International Classification:
A61K 35/12, C07K 7/08, C07K 14/00, A61K 38/10, A61K 38/16, A61K 38/39, C12N 5/071, A61P 43/00
US Classification:
424 937, 530326, 530325, 530324, 514 214, 514 209, 514 172, 435325
Abstract:
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
Implantable Bone Graft Materials
US Patent:
2011011, May 19, 2011
Filed:
Nov 18, 2010
Appl. No.:
12/949069
Inventors:
Mora Carolynne Melican - Cary NC, US
Isaac Gilliam Sanford - Durham NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Isaac Gilliam Sanford - Durham NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Assignee:
AFFINERGY, INC. - Research Triangle Park NC
International Classification:
A61K 9/00, C12N 5/071, C12N 5/078, A61K 35/12, A61K 35/32, A61K 35/28, A61K 35/14, A61K 35/16, A61K 35/48, A61K 35/50, A61K 33/42, A61K 33/10, A61K 33/06, A61K 33/00, A61P 19/08
US Classification:
424426, 435325, 424 937, 424 9372, 424602, 424687, 424682, 424549, 424677
Abstract:
Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.
Methods And Compositions For Capture Of Cells
US Patent:
2011011, May 19, 2011
Filed:
Nov 18, 2010
Appl. No.:
12/949767
Inventors:
Isaac Gilliam Sanford - Durham NC, US
Dalia Isolda Juzumiene - Cary NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Jonathan Allen Hodges - Durham NC, US
Dalia Isolda Juzumiene - Cary NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Jonathan Allen Hodges - Durham NC, US
Assignee:
AFFINERGY, INC. - Research Triangle Park NC
International Classification:
A61K 9/00, C12N 5/071, C12M 1/00, A61K 35/12, C12N 5/073, C12N 5/078, A61P 17/02
US Classification:
424423, 435325, 435378, 435379, 4352831, 424 937
Abstract:
Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.
Methods And Compositions For Soft Tissue Repair
US Patent:
2011011, May 19, 2011
Filed:
Nov 18, 2010
Appl. No.:
12/949104
Inventors:
Isaac Gilliam Sanford - Durham NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Yuchen Chen - Chapel Hill NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Hanne Gron - Durham NC, US
Ganesan Sathya - Cary NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Yuchen Chen - Chapel Hill NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Hanne Gron - Durham NC, US
Ganesan Sathya - Cary NC, US
Assignee:
AFFINERGY, INC. - Research Triangle Park NC
International Classification:
A61K 9/00, C07K 14/00, C07K 7/08, C07K 14/78, C12N 5/071, C12N 5/078, A61K 35/12, A61K 35/32, A61K 35/28, A61K 35/14, A61K 35/16, A61K 35/48, A61K 35/50, C07K 19/00, A61K 38/16, A61K 38/10, A61K 38/39, A61P 17/02, A61P 19/04, A61P 21/00, A61P 19/00, A61P 9/00, C07K 9/00, C08G 63/91, A61K 38/14, A61K 31/765, C12N 5/077
US Classification:
424423, 530326, 530327, 530356, 435325, 424 937, 424 9372, 530324, 530357, 514 214, 514 215, 514 172, 424 7817, 514 94, 514 82, 514 186, 530322, 530353, 525 541, 514 209, 424 783
Abstract:
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
Methods And Compositions For Delivery Of Glycopeptide Antibiotics To Medical Device Surfaces
US Patent:
2010009, Apr 22, 2010
Filed:
Oct 17, 2008
Appl. No.:
12/253750
Inventors:
Martyn Kerry Darby - Chapel Hill NC, US
Isaac Gilliam Sanford - Durham NC, US
Hanne Gron - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Isaac Gilliam Sanford - Durham NC, US
Hanne Gron - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Assignee:
Affinergy, Inc. - Research Triangle Park NC
International Classification:
A61F 2/00, A61K 38/16, A61L 33/12, C07H 21/04, C12N 15/64, A61P 31/04
US Classification:
424423, 514 12, 427 23, 536 231, 4353201
Abstract:
The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.