Inventors:
Martin Stogniew - Blue Bell PA, US
Luigi Colombo - Malnate (VA), IT
Romeo Ciabatti - Novate Milanese, IT
Assignee:
VICURON PHARMACEUTICALS INC. - King of Prussia PA
International Classification:
A61K 38/16
Abstract:
The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A, A, B, B, C, C, isoB, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.