Inventors:
Jerome Aubert - Grasse, FR
Martin Steinhoff - San Francisco CA, US
Assignee:
UNIVERSITAT MUNSTER - Munster
GALDERMA RESEARCH & DEVELOPMENT - Biot
International Classification:
A61K 31/55, A61K 31/357, A61K 31/496, A61K 31/506, A61K 31/538, A61K 31/4439, A61K 31/416, A61K 31/4725, A61K 31/4188, A61K 31/165, A61K 31/451
US Classification:
51421301, 540593, 564161, 514617, 549362, 514452, 544360, 51425301, 544319, 514269, 546206, 514319, 544327, 514256, 5462791, 514343, 5483621, 514406, 546 15, 514278, 544284, 51426621, 5483011, 514389, 544105, 5142305, 435 721
Abstract:
An in vitro method of screening candidate compounds for the preventive or curative treatment of rosacea is described. The method can include determining the capacity of a compound to modulate the expression or activity of the Transient Receptor Potential (TRPs), as well as the use of modulators of the expression or activity of this transcription factor for the treatment of rosacea. The method can also include in vitro diagnosis or prognosis of this pathology.