Inventors:
David Ho - New York NY, US
Martin Markowitz - New York NY, US
MICHEL KLEIN - LYON CEDEX, FR
RAPHAELLE HABIB - LYON CEDEX, FR
International Classification:
C07H021/04, A61K031/70, A01N043/04, A61K039/21, C12N015/00, C12N015/09, C12N015/63, C12N015/70, C12N015/74
US Classification:
536/023720, 435/320100, 424/208100
Abstract:
The present invention provides a method of permitting cessation of antiviral therapy on HIV-infected subjects without virus rebound or with at least a delayed virus rebound or a decreased post rebound set-point. The method comprises the re-induction of HIV-specific immune responses using a vaccination strategy to induce both humoral and cell-mediated immunity. The present invention achieves an immunological control of persistent infectious virus after discontinuation of antiviral therapy. The vaccine strategy according to the invention is both safe and immunogenic in the subject HIV-infected patient population.