Inventors:
Adam Lubin - Norwich VT, US
Martin Lubin - Hanover NH, US
International Classification:
A61K 31/7076, A61K 31/519, A61K 31/53, A61P 31/04, A61P 35/00, C12N 5/00, A61K 31/52, A61K 31/198
US Classification:
514 46, 5142634, 5142621, 514562, 435375, 514243, 51426337
Abstract:
Methods for treating diseases in humans and vertebrate animals are provided using competitive antagonists of cellular metabolites combined with a protective agent for protecting host cells from toxic effects of the drugs. Also provided are kits comprising competitive antagonists and suitable protective agents. In addition, screening methods for identifying competitive antagonists, protective agents and potentiating agents, for use according to the methods of the invention, are provided.