MARTIN J. KORBLING, M.D.
Osteopathic Medicine at Holcombe Blvd, Houston, TX

2009015, Jun 18, 2009

Feb 29, 2008

12/227843

Martin Korbling - Houston TX, US
J. Donald Payne - Kingwood TX, US
Christopher L. Coleman - The Woodlands TX, US
Jon A. Schwartz - Sugar Land TX, US

A61M 1/36

604 502, 604 608, 977735, 977734

Methods and devices are provided for the extracorporeal ablation of target cells circulating in blood of an organism. Exogenous material introduced into the blood preferentially associates with target cells (e.g. cancer cells, bacteria, viruses) in the blood. An extracorporeal continuous flow pathway accesses the patient's blood to apply an external energy source to the blood at an ex vivo ablation device in a portion of the extracorporeal continuous flow pathway. The exogenous material interact with the applied energy so as to result in the damage or death of the target cells. The blood is then returned to the body in a continuous-flow pattern. By applying the energy while the blood is in the ex vivo ablation device, shielding of the target cells by the body is reduced and detrimental effects on the organs and tissues of the body are avoided or mitigated.

2005000, Jan 13, 2005

May 14, 2004

10/846344

Martin Korbling - Houston TX, US
Zeev Estrov - Houston TX, US
Herbert Fritsche - Houston TX, US

G01N033/53, G01N033/567, C12N005/08

435007200, 435372000

The present invention provides a method for assessing stem cell transplant in a protein-containing sample using multi-dimensional protein separation. Such multi-dimensional separation techniques include chromatography, electrophoresis and mass spectrometry. A protein-containing sample may comprise body fluids such as blood and serum but may also include a cell, tissue or organ. Identification of a protein present in the donor and the transplant recipient but not in the recipient sample before transplant indicates that the stem cell is grafted.