MARKUS H FRANK, M.D.
Osteopathic Medicine in Boston, MA
License number
Massachusetts 152270
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
2
75 Francis St Brigham & WOMEN'S HOSP., Boston, MA 02115
9 Brewer St, Cambridge, MA 02138
9 Brewer St, Cambridge, MA 02138
Phone
(617) 732-5850
Personal information
See more information about MARKUS H FRANK at radaris.comName
Address
Phone
9 Brewer St, Cambridge, MA 02138
9 Brewster St, Cambridge, MA 02138
32 Roberts Rd, Cambridge, MA 02138
9 Brewer St, Cambridge, MA 02138
Professional information
Dr. Markus H Frank, Boston MA - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
Brigham and Women's Hospital NEP
75 Francis St, Boston 02115
(617) 732-8239 (Phone)
75 Francis St, Boston 02115
(617) 732-8239 (Phone)
Certifications:
Internal Medicine, 1997
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Brigham and Women's Hospital NEP
75 Francis St, Boston 02115
Brigham and Women's Hospital
75 Francis St, Boston 02115
75 Francis St, Boston 02115
Brigham and Women's Hospital
75 Francis St, Boston 02115
Education:
Medical School
Ruprecht-Karls-Universitaet Heidelberg, Medizinische Gesamtfakultat
Graduated: 1992
Albert Einstein College Of Med
Albert Einstein College Med
Graduated: 1997
Brigham and Womens Hospital Harvard Med School
Graduated: 1999
Harvard Med School
Graduated: 2001
Ruprecht-Karls-Universitaet Heidelberg, Medizinische Gesamtfakultat
Graduated: 1992
Albert Einstein College Of Med
Albert Einstein College Med
Graduated: 1997
Brigham and Womens Hospital Harvard Med School
Graduated: 1999
Harvard Med School
Graduated: 2001
Assistant Professor Of Pediatrics At Harvard Medical School
Position:
Assistant Professor of Pediatrics at Harvard Medical School
Location:
Greater Boston Area
Industry:
Medical Practice
Work:
Harvard Medical School
-
Assistant Professor of Pediatrics
Markus Hermann Frank, Boston MA
Specialties:
Internal Medicine, Nephrology, Pulmonary Disease
Work:
BWH Partner Office for Womens Careers
75 Francis St, Boston, MA 02115
75 Francis St, Boston, MA 02115
Education:
Ruprecht-Karls-Universitaet Heidelberg (1992)
Gene Encoding A Multidrug Resistance Human P-Glycoprotein Homologue On Chromosome 7P15-21 And Uses Thereof
US Patent:
8425876, Apr 23, 2013
Filed:
Feb 9, 2010
Appl. No.:
12/702570
Inventors:
Markus H. Frank - Cambridge MA, US
Mohamed H. Sayegh - Westwood MA, US
Mohamed H. Sayegh - Westwood MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C07K 16/28, C07K 16/30, A61K 51/10
US Classification:
424 149, 5303879, 5303881, 5303888, 5303911, 5303913, 5303917
Abstract:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Gene Encoding A Multidrug-Resistance Human P-Glycoprotein Homologue On Chromosome 7P15-21 And Uses Thereof
US Patent:
8076091, Dec 13, 2011
Filed:
Nov 19, 2008
Appl. No.:
12/273849
Inventors:
Markus H. Frank - Cambridge MA, US
Mohamed H. Sayegh - Boston MA, US
Mohamed H. Sayegh - Boston MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
G01N 33/567, C12N 5/07, C12N 5/074
US Classification:
435 721, 435325, 435366
Abstract:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Gene Encoding A Multidrug-Resistance Human P-Glycoprotein Homologue On Chromosome 7P15-2 And Uses Thereof
US Patent:
7465554, Dec 16, 2008
Filed:
Sep 29, 2004
Appl. No.:
10/952328
Inventors:
Markus H. Frank - Cambridge MA, US
Mohamed H. Sayegh - Westwood MA, US
Mohamed H. Sayegh - Westwood MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
G01N 33/543
US Classification:
435 723, 436501, 436518
Abstract:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Tumor Suppressors Associated With Human Chromosome 21Q22
US Patent:
2003011, Jun 26, 2003
Filed:
Nov 26, 2002
Appl. No.:
10/303995
Inventors:
Markus Frank - Cambridge MA, US
Assignee:
The Brigham and Women's Hospital, Inc.
International Classification:
C12Q001/68, C07H021/04, C12P021/02, C12N005/06, C07K014/47
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200
Abstract:
The present invention is directed to tumor suppressor polypeptides and to polynucleotide sequences by which they are encoded. It includes assays designed for detecting mutations that predispose a patient to certain forms of cancer and therapeutic methods in which suppressor proteins or genes encoding the proteins are administered to patients.
Therapeutic And Diagnostic Methods Relating To Cancer Stem Cells
US Patent:
2011028, Nov 24, 2011
Filed:
Nov 13, 2009
Appl. No.:
13/128915
Inventors:
Markus H. Frank - Cambridge MA, US
Natasha Y. Frank - Cambridge MA, US
Natasha Y. Frank - Cambridge MA, US
Assignee:
The Brigham and Womens Hospital, Inc. - Boston MA
International Classification:
A61K 39/395, A61P 35/00, C40B 40/06, C12Q 1/02, C12N 5/02, A61K 31/7088, C12Q 1/68
US Classification:
4241781, 514 44 A, 435 614, 435 29, 435375, 506 17
Abstract:
Genes that are deregulated in cancer stem cells (e.g., melanoma stem cells) are disclosed. Methods which involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes are used to treat individuals having melanoma. Cell surface genes that are upregulated in melanoma stem cells are targeted for the selective isolation, detection, and killing of cancer stem cells in melanoma.
Targeting Abcb5 For Cancer Therapy
US Patent:
7928202, Apr 19, 2011
Filed:
Apr 11, 2008
Appl. No.:
12/101428
Inventors:
Markus H. Frank - Cambridge MA, US
Natasha Y. Frank - Cambridge MA, US
Mohamed H. Sayegh - Boston MA, US
Natasha Y. Frank - Cambridge MA, US
Mohamed H. Sayegh - Boston MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
C07K 16/00
US Classification:
5303873, 5303877, 5303879, 5303897, 5303911, 5303913, 5303917
Abstract:
The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
Targeting Abcb5 For Cancer Therapy
US Patent:
2011016, Jul 7, 2011
Filed:
Mar 10, 2011
Appl. No.:
13/044854
Inventors:
Markus H. Frank - Cambridge MA, US
Natasha Y. Frank - Cambridge MA, US
Mohamed H. Sayegh - Westwood MA, US
Natasha Y. Frank - Cambridge MA, US
Mohamed H. Sayegh - Westwood MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 39/395, C12N 5/071, A61K 38/10, A61K 38/16, A61P 35/00
US Classification:
4241301, 435325, 514 193
Abstract:
The invention related to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.