DR. MARKEY MCNUTT, M.D., PH.D.
Student, Health Care at Medical District Dr, Dallas, TX
License number
Texas P2898
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
License number
Texas P2898
Category
Student, Health Care
Type
Student in an Organized Health Care Education/Training Program
Address
Address
1935 Medical District Dr, Dallas, TX 75235
Phone
(214) 456-2735
Professional information
Markey McNutt, Dallas TX
Work:
Grad. Medical Educ.
5201 Harry Hines Blvd, Dallas, TX 75235
5201 Harry Hines Blvd, Dallas, TX 75235
Cell-Based Pcsk9 Screening Assay
US Patent:
2009027, Nov 5, 2009
Filed:
Apr 30, 2008
Appl. No.:
12/112615
Inventors:
Jay D. Horton - Plano TX, US
Markey C. McNutt - Dallas TX, US
Markey C. McNutt - Dallas TX, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 33/53
US Classification:
435 76
Abstract:
The present invention includes a PCSK9 activity inhibition assay system, kits, compositions and methods. The present invention includes a cell having a first vector capable of expressing a catalytic fragment of PCSK9, a second vector capable of expressing a prodomain of PCSK9 and a V5 protein with a detectable label. The V5 protein forms a fusion protein with the prodomain of PCSK9 and wherein cleavage of the prodomain by the catalytic fragment of PCSK9 releases a detectable signal.