MARK WILLIAM PERLIN
Medical Practice in Pittsburgh, PA

6750011, Jun 15, 2004

Mar 2, 1999

09/262506

Mark W. Perlin - Pittsburgh PA 15217

C12Q 170

435 6, 435 912, 702 19, 702 20

A method of genotyping including the steps of obtaining nucleic acid material. There is the step of amplifying a short tandem repeat polymorphism of the material to produce a signal. There is the step of analyzing the signal using a computing device with a memory. There is the step of producing an allele of the polymorphism.

6807490, Oct 19, 2004

Feb 15, 2000

09/504389

Mark W. Perlin - Pittsburgh PA 15217

G06F 1900

702 20, 435 6, 435 912, 536 231

The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA samples data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.

5604100, Feb 18, 1997

Jul 19, 1995

8/504400

Mark W. Perlin - Pittsburgh PA

C12Q 168, C12P 1934

435 6

The present invention pertains to a method for sequencing genomes. The method comprises the steps of obtaining nucleic acid material from a genome. Then there is the step of constructing a clone library and one or more probe libraries from the nucleic acid material. Next there is the step of comparing the libraries to form comparisons. Then there is the step of combining the comparisons to construct a map of the clones relative to the genome. Next there is the step of determining the sequence of the genome by means of the map. The present invention also pertains to a system for sequencing a genome. The system comprises a mechanism for obtaining nucleic acid material from a genome. The system also comprises a mechanism for constructing a clone library and one or more probe libraries. The constructing mechanism is in communication with the nucleic acid material from a genome. Additionally, the system comprises a mechanism for comparing said libraries to form comparisons.

2009009, Apr 9, 2009

Oct 9, 2007

11/973583

Mark W. Perlin - Pittsburgh PA, US

G06Q 99/00

705 1

The present invention pertains to a process for determining reliability of forensic interpretation methods. Specifically, the process comprises the steps of obtaining forensic data, a known feature, and a population of features; obtaining a forensic interpretation method that is applicable to the forensic data; applying the interpretation method to the forensic data to obtain an inferred feature; computing a match information statistic that determines a frequency of occurrence of a match between the inferred feature and the known feature relative to the population of features; and computing a numerical reliability statistic from the match information statistic to determine the reliability of the forensic interpretation method for legal admissibility in a court of law. This reliability determination is useful for validating a forensic interpretation method so that its results can be admitted as evidence in a court of law. Establishing reliability helps ensure that forensic evidence complies with F.R.E. 702, which requires that a method and the application of the method to data must be reliable in order to be admissible.

5622823, Apr 22, 1997

Oct 14, 1994

8/323532

Mark W. Perlin - Pittsburgh PA

C12N 1510, C12Q 168

435 6

The present invention pertains to a process for efficiently and accurately constructing indirectly high-resolution maps of genomes and other entities. Specifically, the process comprises the steps of generating three sets of reagents, namely, (1) sample points, (2) covering regions, and (3) probes; performing parallel experiments to efficiently compare these reagents and acquire two data tables, one of (a) probes with covering regions, and another of (b) covering regions with sample points; combining these two independent tables by means of an inner product operation to produce a third table that indirectly compares probes with sample points; analyzing this computed table to construct a high-resolution map of the probes, the sample points, and the covering regions. The resulting integrated map is then used to efficiently search for probes based on their proximity to selected sample points. With genome maps, this search can enable the rapid discovery of genes, their products, and their useful applications.

2010001, Jan 14, 2010

Sep 12, 2009

12/584761

Mark W. Perlin - Pittsburgh PA, US

G06F 19/00, G01N 33/48

702 19

The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.

2005004, Feb 24, 2005

Sep 8, 2004

10/935966

Mark Perlin - Pittsburgh PA, US

C12Q001/68

435006000

The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.

6054268, Apr 25, 2000

Oct 21, 1996

8/734717

Mark W. Perlin - Pittsburgh PA

C12Q 168, C12P 1934, G06K 920

435 6

The present invention pertains to a process which can be fully automated for accurately determining the alleles of genetic markers. More specifically, the present invention is related to performing PCR amplification on locations of DNA to generate a reproducible pattern, labeling the PCR products, converting the labels into a signal, operating on the signal, and then determining the genotype of the location of the DNA. An amplification can include multiple locations from the DNA of one or more individuals. The invention also pertains to genetics applications and systems which can effectively use this genotyping information.

2004024, Dec 2, 2004

May 4, 2004

10/838764

Mark Perlin - Pittsburgh PA, US

C12Q001/68, G06F019/00, G01N033/48, G01N033/50, C12P019/34

435/006000, 435/091200, 702/020000, 205/777500

A method for genotyping including the steps of obtaining nucleic acid material from a genome. Then there is the step of amplifying a location of the material. Next there is the step of assaying the amplified material based on size and concentration. Then there is the step of converting the assayed amplified material into a first set of electrical signals corresponding to size and concentration of the amplified material at the location. Then there is the step of operating on the first set of electrical signals produced from the amplified material with a second set of electrical signals corresponding to a response pattern of the location to produce a third set of clean electrical signals corresponding to the size and multiplicities of the unamplified material on the genome at the location. A system for genotyping.

5876933, Mar 2, 1999

Jul 24, 1996

8/685528

Mark W. Perlin - Pittsburgh PA

C12Q 168, C12P 1934

435 6

The present invention pertains to a process which can be fully automated for accurately determining the alleles of genetic markers. More specifically, the present invention is related to performing PCR amplification on locations of DNA to generate a reproducible pattern, labeling the PCR products, converting the labels into a signal, operating on the signal, and then determining the genotype of the location of the DNA. An amplification can include multiple locations from the DNA of one or more individuals. The invention also pertains to genetics applications and systems which can effectively use this genotyping information.