MARK WILLIAM PERLIN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD034506E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15217
Personal information
See more information about MARK WILLIAM PERLIN at radaris.comName
Address
Phone
5885 Marlborough Rd, Pittsburgh, PA 15217
5904 Beacon St, Pittsburgh, PA 15217
5904 Beacon St, Pittsburgh, PA 15217
5885 Marlborough Rd, Pittsburgh, PA 15217
Professional information
Method And System For Genotyping
US Patent:
6750011, Jun 15, 2004
Filed:
Mar 2, 1999
Appl. No.:
09/262506
Inventors:
Mark W. Perlin - Pittsburgh PA 15217
International Classification:
C12Q 170
US Classification:
435 6, 435 912, 702 19, 702 20
Abstract:
A method of genotyping including the steps of obtaining nucleic acid material. There is the step of amplifying a short tandem repeat polymorphism of the material to produce a signal. There is the step of analyzing the signal using a computing device with a memory. There is the step of producing an allele of the polymorphism.
Method For Dna Mixture Analysis
US Patent:
6807490, Oct 19, 2004
Filed:
Feb 15, 2000
Appl. No.:
09/504389
Inventors:
Mark W. Perlin - Pittsburgh PA 15217
International Classification:
G06F 1900
US Classification:
702 20, 435 6, 435 912, 536 231
Abstract:
The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA samples data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.
Method And System For Sequencing Genomes
US Patent:
5604100, Feb 18, 1997
Filed:
Jul 19, 1995
Appl. No.:
8/504400
Inventors:
Mark W. Perlin - Pittsburgh PA
International Classification:
C12Q 168, C12P 1934
US Classification:
435 6
Abstract:
The present invention pertains to a method for sequencing genomes. The method comprises the steps of obtaining nucleic acid material from a genome. Then there is the step of constructing a clone library and one or more probe libraries from the nucleic acid material. Next there is the step of comparing the libraries to form comparisons. Then there is the step of combining the comparisons to construct a map of the clones relative to the genome. Next there is the step of determining the sequence of the genome by means of the map. The present invention also pertains to a system for sequencing a genome. The system comprises a mechanism for obtaining nucleic acid material from a genome. The system also comprises a mechanism for constructing a clone library and one or more probe libraries. The constructing mechanism is in communication with the nucleic acid material from a genome. Additionally, the system comprises a mechanism for comparing said libraries to form comparisons.
Method And System For Determining The Reliability Of Forensic Interpretation
US Patent:
2009009, Apr 9, 2009
Filed:
Oct 9, 2007
Appl. No.:
11/973583
Inventors:
Mark W. Perlin - Pittsburgh PA, US
International Classification:
G06Q 99/00
US Classification:
705 1
Abstract:
The present invention pertains to a process for determining reliability of forensic interpretation methods. Specifically, the process comprises the steps of obtaining forensic data, a known feature, and a population of features; obtaining a forensic interpretation method that is applicable to the forensic data; applying the interpretation method to the forensic data to obtain an inferred feature; computing a match information statistic that determines a frequency of occurrence of a match between the inferred feature and the known feature relative to the population of features; and computing a numerical reliability statistic from the match information statistic to determine the reliability of the forensic interpretation method for legal admissibility in a court of law. This reliability determination is useful for validating a forensic interpretation method so that its results can be admitted as evidence in a court of law. Establishing reliability helps ensure that forensic evidence complies with F.R.E. 702, which requires that a method and the application of the method to data must be reliable in order to be admissible.
System And Method For Producing Maps And Cloning Genes Therefrom
US Patent:
5622823, Apr 22, 1997
Filed:
Oct 14, 1994
Appl. No.:
8/323532
Inventors:
Mark W. Perlin - Pittsburgh PA
International Classification:
C12N 1510, C12Q 168
US Classification:
435 6
Abstract:
The present invention pertains to a process for efficiently and accurately constructing indirectly high-resolution maps of genomes and other entities. Specifically, the process comprises the steps of generating three sets of reagents, namely, (1) sample points, (2) covering regions, and (3) probes; performing parallel experiments to efficiently compare these reagents and acquire two data tables, one of (a) probes with covering regions, and another of (b) covering regions with sample points; combining these two independent tables by means of an inner product operation to produce a third table that indirectly compares probes with sample points; analyzing this computed table to construct a high-resolution map of the probes, the sample points, and the covering regions. The resulting integrated map is then used to efficiently search for probes based on their proximity to selected sample points. With genome maps, this search can enable the rapid discovery of genes, their products, and their useful applications.
Method And System For Dna Analysis
US Patent:
2010001, Jan 14, 2010
Filed:
Sep 12, 2009
Appl. No.:
12/584761
Inventors:
Mark W. Perlin - Pittsburgh PA, US
International Classification:
G06F 19/00, G01N 33/48
US Classification:
702 19
Abstract:
The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.
Method And System For Dna Analysis
US Patent:
2005004, Feb 24, 2005
Filed:
Sep 8, 2004
Appl. No.:
10/935966
Inventors:
Mark Perlin - Pittsburgh PA, US
International Classification:
C12Q001/68
US Classification:
435006000
Abstract:
The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.
Method And System For Genotyping
US Patent:
6054268, Apr 25, 2000
Filed:
Oct 21, 1996
Appl. No.:
8/734717
Inventors:
Mark W. Perlin - Pittsburgh PA
International Classification:
C12Q 168, C12P 1934, G06K 920
US Classification:
435 6
Abstract:
The present invention pertains to a process which can be fully automated for accurately determining the alleles of genetic markers. More specifically, the present invention is related to performing PCR amplification on locations of DNA to generate a reproducible pattern, labeling the PCR products, converting the labels into a signal, operating on the signal, and then determining the genotype of the location of the DNA. An amplification can include multiple locations from the DNA of one or more individuals. The invention also pertains to genetics applications and systems which can effectively use this genotyping information.
Method And System For Genotyping
US Patent:
2004024, Dec 2, 2004
Filed:
May 4, 2004
Appl. No.:
10/838764
Inventors:
Mark Perlin - Pittsburgh PA, US
International Classification:
C12Q001/68, G06F019/00, G01N033/48, G01N033/50, C12P019/34
US Classification:
435/006000, 435/091200, 702/020000, 205/777500
Abstract:
A method for genotyping including the steps of obtaining nucleic acid material from a genome. Then there is the step of amplifying a location of the material. Next there is the step of assaying the amplified material based on size and concentration. Then there is the step of converting the assayed amplified material into a first set of electrical signals corresponding to size and concentration of the amplified material at the location. Then there is the step of operating on the first set of electrical signals produced from the amplified material with a second set of electrical signals corresponding to a response pattern of the location to produce a third set of clean electrical signals corresponding to the size and multiplicities of the unamplified material on the genome at the location. A system for genotyping.
Method And System For Genotyping
US Patent:
5876933, Mar 2, 1999
Filed:
Jul 24, 1996
Appl. No.:
8/685528
Inventors:
Mark W. Perlin - Pittsburgh PA
International Classification:
C12Q 168, C12P 1934
US Classification:
435 6
Abstract:
The present invention pertains to a process which can be fully automated for accurately determining the alleles of genetic markers. More specifically, the present invention is related to performing PCR amplification on locations of DNA to generate a reproducible pattern, labeling the PCR products, converting the labels into a signal, operating on the signal, and then determining the genotype of the location of the DNA. An amplification can include multiple locations from the DNA of one or more individuals. The invention also pertains to genetics applications and systems which can effectively use this genotyping information.