Inventors:
David R. Sibley - Gaithersburg MD, US
Frederick J. Monsma, Jr. - Riehen, CH
Mark Hamblin - Seattle WA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12N 500, C12N 1500, C12Q 168, C07K 14435
US Classification:
435325, 435 6, 435 691, 4353201, 536 235, 530350
Abstract:
Genes encoding the St-B17 serotonin receptor protein were cloned and characterized from a rat striatum mRNA and a human genomic library. The St-B17 receptor has nucleotide and amino acid homology with previously described 5-HT genes and can bind ligands that are known to interact with serotonin receptors. In addition, the levels of intracellular cAMP in cells transfected with the receptor gene respond in a dose dependent manner to introduction of serotonin in the media.