Inventors:
Adam Ian Kaplin - Baltimore MD, US
Mark T. Worthington - Prescott AZ, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 38/02, A61K 38/07, A61K 38/10, A61K 38/17, A61K 38/08, A61K 38/19, A61P 37/06, A61P 37/02, A61P 1/00, A61P 29/00, A61P 19/02, A61P 3/10, A61P 3/00, A61P 5/14, A61P 1/16, A61P 5/38, A61K 39/395
US Classification:
424 851, 4242781, 4241731, 4241331, 4241421
Abstract:
The present invention provides compositions and methods for treating and/or preventing an autoimmune disease comprising administering to a subject in need thereof an effective amount of cyclophosphamide and/or a cyclophosphamide derivative in combination with an additional immunomodulatory agent.