Inventors:
R. James White - Rochester NY, US
Mark B. Taubman - Rochester NY, US
Assignee:
University of Rochester - Rochester NY
International Classification:
A61K 39/395
US Classification:
514 145, 4241411, 4241431, 4241841, 514 133, 514 157, 524297
Abstract:
An improved non-human animal model of severe pulmonary arterial hypertension (PAH) and its use for testing of therapeutic agents that can treat symptoms of PAH are disclosed. In addition, the present application relates to the identification of several classes of therapeutic agents that, alone or in combination, can be used to treat or prevent PAH or at least reduce the severity of symptoms associated therewith. Both gene therapy and non-gene therapy approaches are described.