Inventors:
Mark S. Kaminski - Ann Arbor MI
Gregory M. Butchko - Lake Forest IL
Stephan D. Glenn - Sunnyvale CA
Richard L. Wahl - Ann Arbor MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
Coulter Pharmaceutical, Inc. - South San Francisco CA
International Classification:
A61K 5100, A61K 39395, C12P 2108, C07K 1600
Abstract:
Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.