DR. MARK S GOLD, MD
Osteopathic Medicine at Archer Rd, Gainesville, FL

2007025, Nov 8, 2007

Feb 28, 2005

10/588749

Richard Melker - Gainesville FL, US
James Sackellares - Gainesville FL, US
Mark Gold - Gainesville FL, US
Donn Dennis - Gainesville FL, US

A61K 9/51

424009100

Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.

2005005, Mar 10, 2005

Feb 26, 2004

10/788501

Richard Melker - Gainesville FL, US
James Sackellares - Gainesville FL, US
Mark Gold - Gainesville FL, US

A61B005/08, A61M037/00

600532000, 604019000

The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.

2002017, Nov 28, 2002

May 22, 2002

10/154201

Richard Melker - Gainesville FL, US
Bruce Goldberger - Gainesville FL, US
Mark Gold - Gainesville FL, US

G01N033/00

436/151000, 436/173000, 422/083000, 422/082010

The present invention includes a method and apparatus for detecting use of illicit substances by analyzing a sample of breath using electronic sensor technology, including surface acoustic-wave gas sensor technology. The method determines the presence and concentration of the substance (or a class of substances). Diagnostic software is used to identify substances where a stored library of signatures is compared to the signature obtained from the system. Signal processing and neural networks are preferably utilized in the analysis.

2008005, Mar 6, 2008

Sep 20, 2005

11/578322

Richard Melker - Gainesville FL, US
Mark Gold - Gainesville FL, US

G06Q 50/00

705002000

The subject invention provides systems and methods for monitoring prescription medications. In particular, systems and methods are provided for monitoring patient compliance with a given prescribed regimen as well as monitoring the origins of a prescription drug. The subject invention provides a central computer and a portable device, wherein the portable device includes at least one sensor for detecting a target marker. The target marker of the invention represents either the presence of a specific prescribed medication or identify the proper origins of a medication.

7052468, May 30, 2006

May 22, 2002

10/153096

Richard J. Melker - Gainesville FL, US
Mark Gold - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL

A61B 5/08, G01N 1/22

600532, 600529, 73 233

The present invention includes a method and apparatus for detecting exposure to environmental tobacco smoke by analyzing a sample of breath using electronic sensor technology, including surface acoustic-wave gas sensor technology. The method determines the presence and concentration of substance(s) (or a class of substances) indicative of environmental smoke exposure. Diagnostic software is used to identify substances where a stored library of signatures is compared to the signature obtained from the system. Signal processing and neural networks are preferably utilized in the analysis.

2007016, Jul 19, 2007

Dec 13, 2005

11/301911

Richard Melker - Gainesville FL, US
Donn Dennis - Gainesville FL, US
David Bjoraker - Gainesville FL, US
Mark Gold - Gainesville FL, US

A61B 5/08

600532000, 600529000

The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.

2006006, Mar 23, 2006

Sep 20, 2004

10/945732

Richard Melker - Gainesville FL, US
Mark Gold - Gainesville FL, US

A61K 49/00

424010100

The subject invention provides systems and methods for monitoring prescription medications. In particular, systems and methods are provided for monitoring patient compliance with a given prescribed regimen as well as monitoring the origins of a prescription drug. The subject invention provides a central computer and a portable device, wherein the portable device includes at least one sensor for detecting a target marker. The target marker of the invention represents either the presence of a specific prescribed medication or identify the proper origins of a medication.