Inventors:
Mark Denison - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A61K 39/12, A61K 35/76, A61P 31/00
Abstract:
The present invention is directed live, attenuated Nidovirus vaccines, and in a particular embodiment, to coronavirus vaccines. The vaccine comprises a viral genome encoding a replicase polyprotein having at least one proteinase cleavage site that exhibits reduced or no cleavage. Such viruses show reduced.