Inventors:
Annabelle Friera - South San Francisco CA, US
Brian R. Wong - San Mateo CA, US
Esteban Masuda - Menlo Park CA, US
Mark Powell - Burlingame CA, US
Assignee:
Rigel Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
C12Q 1/02, C12Q 1/48, G01N 33/566
US Classification:
435 724, 435 15, 435 29, 436 63, 436501
Abstract:
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.