Inventors:
Neal Rosen - Englewood NJ, US
Laura Sepp-Lorenzino - Landsdale PA, US
Mark Moasser - San Francisco CA, US
Allen Oliff - Gwynedd Valley PA, US
Jackson Gibbs - Chalfont PA, US
Nancy Kohl - Wellesley MA, US
Samuel Graham - Schwenksville PA, US
George Prendergast - Bala-Cynwyd PA, US
International Classification:
A61K031/496, A61K031/495
US Classification:
514253010, 514255010, 514254050
Abstract:
The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.