Mark L Tykocinski
Medical Practice in Philadelphia, PA
License number
New Jersey 25MA09353500
Issued Date
Jul 25, 2013
Expiration Date
Jun 30, 2017
Category
Medical Examiners
Type
Medical Doctor
Address
Address
Philadelphia, PA
Organization information
See more information about Mark L Tykocinski at bizstanding.comJefferson Medical College - Mark L Tykocinski MD
1025 Walnut St #100, Philadelphia, PA 19107
Categories:
Colleges & Universities, Medical Schools
Phone:
(215) 955-6980 (Phone)
Professional information
Chair, Department Of Pathology And Laboratory Medicine At University Of Pennsylvania
Position:
Chair, Department of Pathology and Laboratory Medicine at University of Pennsylvania
Location:
Greater Philadelphia Area
Industry:
Hospital & Health Care
Work:
University of Pennsylvania
-
Chair, Department of Pathology and Laboratory Medicine
Mark Tykocinski, Philadelphia PA
Work:
Hospital Of The U Of Pennsylvania
3400 Spruce St, Philadelphia, PA 19175
3400 Spruce St, Philadelphia, PA 19175
Dr. Mark L Tykocinski, Philadelphia PA - MD (Doctor of Medicine)
Specialties:
Anatomic & Clinical Pathology, Allergy & Immunology, Immunology
Address:
1025 Walnut St STE 100, Philadelphia 19107
3400 Spruce St, Philadelphia 19104
(215) 662-6880 (Phone), (215) 349-5325 (Fax)
3400 Spruce St, Philadelphia 19104
(215) 662-6880 (Phone), (215) 349-5325 (Fax)
Languages:
English
Hospitals:
1025 Walnut St STE 100, Philadelphia 19107
3400 Spruce St, Philadelphia 19104
Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia 19104
3400 Spruce St, Philadelphia 19104
Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia 19104
Education:
Medical School
New York University
Graduated: 1978
New York University
Graduated: 1978
Auto-Stimulating Cells And Methods For Making And Using The Same
US Patent:
7435585, Oct 14, 2008
Filed:
Jul 25, 2002
Appl. No.:
10/205524
Inventors:
Mark L. Tykocinski - Philadelphia PA, US
Guoxing Zheng - Philadelphia PA, US
Guoxing Zheng - Philadelphia PA, US
Assignee:
University of Pennsylvania - Philadelphia PA
International Classification:
C12N 5/00, C12N 5/02, C12N 5/06, C12N 5/16
US Classification:
435325, 435326, 435328, 435329
Abstract:
Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. The fusion protein is transferred to a cell by binding to a lipidated protein, which has been incorporated into the cell membrane. In an additional aspect of the invention, methods of making fusion proteins having cis signaling capabilities, as well as the ability to bind with receptors on the cell's own surface, are provided. Fusion proteins incorporating GPI or a homing element, and a costimulator or inhibitor domain can also be directly transferred to the cell surface. Methods for using cells which have undergone protein transfer according to the present methods are also disclosed. This includes use in a cancer vaccine, use for treatment of cancer or autoimmune disease, and use in determining costimulator threshold levels.