MARK L TYKOCINSKI
Medical Practice in Merion Station, PA
License number
Pennsylvania MD066595L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Merion Station, PA 19066
Professional information
Pp14 Fusion Proteins And Methods For Making And Using The Same
US Patent:
6797489, Sep 28, 2004
Filed:
Oct 29, 2002
Appl. No.:
10/169687
Inventors:
Mark L. Tykocinski - Merion Station PA
Gregory J. Riely - Cleveland Heights OH
Gregory J. Riely - Cleveland Heights OH
Assignee:
TR Associates, L.L.C. - Merion Station PA
International Classification:
C12P 2106
US Classification:
435 691, 4353201, 435325, 4352523, 514 2, 530350
Abstract:
Novel fusion proteins comprising PP14 are disclosed. The fusion proteins retain the immunoregulatory function of native PP14, but offer significant advantages. Methods for using the fusion proteins, and sequence encoding the same in the treatment of immune system diseases and disorders are therefore also disclosed, as are methods for recombinant production of the present fusion proteins.
Novel Chimeric Proteins
US Patent:
2011004, Feb 17, 2011
Filed:
Jun 22, 2009
Appl. No.:
12/488797
Inventors:
Mark L. Tykocinski - Merion Station PA, US
Jui Han Huang - Wallingford PA, US
Jui Han Huang - Wallingford PA, US
International Classification:
A61K 38/16, C07K 19/00, A61K 31/7088, G01N 33/00, A61P 31/00, A61P 37/00, A61P 35/00
US Classification:
800 3, 530350, 5303873, 514 193, 514 37, 514 11, 514 44 R
Abstract:
Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second cell; the second portion sends its own trans signal to the second cell. Methods for making and using these proteins in the treatment of cancer, viral infections, autoimmune and alloimmune diseases are also disclosed, as are pharmaceutical formulations comprising the novel chimeric proteins and genes. Either the proteins themselves or a genetic sequence encoding the protein can be administered. Other methods are also disclosed in which two molecular components result in decrement of a first trans signal from a first cell and the conferring of a second trans signal to a second cell.
Pp14 Fusion Proteins And Methods For Making And Using The Same
US Patent:
2005009, May 5, 2005
Filed:
Jul 27, 2004
Appl. No.:
10/899863
Inventors:
Mark Tykocinski - Merion Station PA, US
Gregory Riely - Cleveland Heights OH, US
Gregory Riely - Cleveland Heights OH, US
International Classification:
A61K038/17, C07H021/04, C12P021/04, A61K039/00, C07K014/47
US Classification:
514012000, 435069700, 435320100, 435325000, 530350000, 536023500, 424192100
Abstract:
Novel fusion proteins comprising PP14 are disclosed. The fusion proteins retain the immunoregulatory function of native PP14, but offer significant advantages. Methods for using the fusion proteins, and sequence encoding the same in the treatment of immune system diseases and disorders are therefore also disclosed, as are methods for recombinant production of the present fusion proteins.
Method For Protein Transfer
US Patent:
6316256, Nov 13, 2001
Filed:
Jan 3, 2000
Appl. No.:
9/476828
Inventors:
Mark L. Tykocinski - Merion Station PA
Aoshuang Chen - Wayne PA
Guoxing Zheng - Wayne PA
Aoshuang Chen - Wayne PA
Guoxing Zheng - Wayne PA
Assignee:
TR Associates, L.L.C. - Chicago IL
International Classification:
C12N 500, C12N 502, C12N 506, C12N 516
US Classification:
435325
Abstract:
Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. The fusion protein is transferred to a cell by binding to a lipidated protein, which has been incorporated into the cell membrane. Methods for using cells which have undergone protein transfer according to the present methods are also disclosed. This includes use in a cancer vaccine, use for treatment of cancer or autoimmune disease, and use in determining costimulator threshold levels.
Cells Having Transferred Proteins, And Methods Of Use Thereof
US Patent:
2004016, Aug 19, 2004
Filed:
Feb 10, 2004
Appl. No.:
10/775942
Inventors:
Mark Tykocinski - Merion Station PA, US
Aoshuang Chen - Wayne PA, US
Guoxing Zheng - Wayne PA, US
Aoshuang Chen - Wayne PA, US
Guoxing Zheng - Wayne PA, US
International Classification:
G01N033/567, G01N033/574
US Classification:
435/007210, 435/007230
Abstract:
Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. The fusion protein is transferred to a cell by binding to a lipidated protein, which has been incorporated into the cell membrane. Methods for using cells which have undergone protein transfer according to the present methods are also disclosed. This includes use in a cancer vaccine, use for treatment of cancer or autoimmune disease, and use in determining costimulator threshold levels.
Methods For Protein Transfer
US Patent:
2002003, Mar 28, 2002
Filed:
Sep 20, 2001
Appl. No.:
09/957056
Inventors:
Mark Tykocinski - Merion Station PA, US
Aoshuang Chen - Wayne PA, US
Guoxing Zheng - Wayne PA, US
Aoshuang Chen - Wayne PA, US
Guoxing Zheng - Wayne PA, US
International Classification:
A61K048/00, A61K039/00, C12N005/08
US Classification:
435/325000, 424/277100, 424/093210
Abstract:
Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. The fusion protein is transferred to a cell by binding to a lipidated protein, which has been incorporated into the cell membrane. Methods for using cells which have undergone protein transfer according to the present methods are also disclosed. This includes use in a cancer vaccine, use for treatment of cancer or autoimmune disease, and use in determining costimulator threshold levels.
Fn14/Trail Fusion Proteins And Method Of Treating Cancer
US Patent:
8329657, Dec 11, 2012
Filed:
Aug 11, 2011
Appl. No.:
13/208091
Inventors:
Mark L. Tykocinski - Merion Station PA, US
Marjaneh Razmara - Philadelphia PA, US
Marjaneh Razmara - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 38/16, C07K 14/715, C07K 14/52, C07K 19/00
US Classification:
514 193, 514 122, 514 133, 514 189, 514 194, 514 196, 514 212, 435 697, 530300, 530350, 530351, 530402
Abstract:
Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well as other diseases such as alloimmune diseases and cancer.
Fn 14/Trail Fusion Proteins
US Patent:
2013006, Mar 14, 2013
Filed:
Aug 15, 2012
Appl. No.:
13/586479
Inventors:
Mark L. Tykocinski - Merion Station PA, US
Marjaneh Razmara - Philadelphia PA, US
Marjaneh Razmara - Philadelphia PA, US
International Classification:
A61K 38/16, A61K 31/7088
US Classification:
514 11, 514 44 R
Abstract:
Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well as other diseases such as alloimmune diseases and cancer.
Ox40/Trail Fusion Proteins
US Patent:
2012012, May 17, 2012
Filed:
Mar 11, 2010
Appl. No.:
13/256401
Inventors:
Mark Tykocinski - Merion Station PA, US
International Classification:
A61K 38/17, A61P 37/06, A61P 25/00, C07K 19/00, A61P 35/00
US Classification:
4241921, 530350, 4242781
Abstract:
Fusion proteins which act on the OX40/TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, and alloimmune diseases, as well as cancer.
Fn14/Trail Fusion Proteins
US Patent:
8039437, Oct 18, 2011
Filed:
Jun 30, 2009
Appl. No.:
12/494680
Inventors:
Mark L. Tykocinski - Merion Station PA, US
Marjaneh Razmara - Philadelphia PA, US
Marjaneh Razmara - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 38/16, C07K 14/715, C07K 14/52, C12N 15/00
US Classification:
514 122, 514 189, 514 213, 514 212, 435 697, 530300, 530350, 530351
Abstract:
Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well as other diseases such as alloimmune diseases and cancer.