Inventors:
Lei Wei - Fishers IN, US
Robert Schwartz - Houston TX, US
Jiang Chang - Houston TX, US
Mark Entman - Houston TX, US
Assignee:
BAYLOR COLLEGE OF MEDICINE - Houston TX
International Classification:
A61K 38/17, A61K 48/00
Abstract:
The present invention is directed to the treatment and/or prevention of disease as it relates to Rho kinase. In specific embodiments, disease is treated and/or prevented through the administration of an agent that selectively inhibits ROCK1. In specific embodiments, it inhibits ROCK1 and not ROCK2. In other specific embodiments, the disease is cardiac disease.