Mark E. Kleinman
Medical Practice in Lexington, KY
License number
Kentucky 44136
Issued Date
Mar 17, 2011
Expiration Date
Feb 28, 2018
Category
Ophthalmology
Type
Faculty
Address
Address
740 S Limestone St, Ophthalmology STE C-300, Lexington, KY 40536
Education
New York University School of Medicine, 2005
Phone
(859) 323-9819 (Work)
Personal information
See more information about Mark E. Kleinman at radaris.comName
Address
Phone
280 S Ashland Ave, Lexington, KY 40502
Professional information
See more information about Mark E. Kleinman at trustoria.com
Assistant Professor Of Ophthalmology And Visual Sciences At University Of Kentucky Healthcare
Assistant Professor Of Ophthalmology And Visual Sciences At University Of Kentucky Healthcare
Position:
Assistant Professor of Ophthalmology and Visual Sciences at University of Kentucky HealthCare
Location:
Lexington, Kentucky Area
Industry:
Higher Education
Work:
University of Kentucky HealthCare
- Lexington since Jul 2013
-
Assistant Professor of Ophthalmology and Visual Sciences
University of Kentucky
- Lexington, Kentucky Area Jul 2011 - Jun 2013
-
Vitreoretinal Surgery Fellow
University of Kentucky
2008 - Jun 2011
-
Resident Physician in Ophthalmology
University of Kentucky
Jul 2006 - Jul 2008
-
Post-doctoral Fellowship
NYU Medical Center
Jun 2005 - Jun 2006
-
Surgery Internship
NYU School of Medicine
Mar 2005 - May 2006
-
Researcher
Smile Train
Jun 2002 - Jun 2005
-
Medical Student Liason
NYU School of Medicine
Mar 2002 - May 2005
-
Researcher in Vascular Biology
Emory University
Jan 1996 - May 1998
-
Researcher in Vascular Biology
Education:
Emory University 1994 - 1998
Degree: B.S, Biology/Chemistry Community Activities
New York University School of Medicine
Degree: M.D
Degree: B.S, Biology/Chemistry Community Activities
New York University School of Medicine
Degree: M.D
Honor & Awards:
Honors and Awards:
2003 NFFR/Young Investigator Grant
2003 SPD/Weston Research Grant
2005 Rosenbluth Travel Award
2007 NEI/ARVO Travel Award
2008 Charles D. Kelman Scholar Award
2009 AUPO/RPB Resident Research Forum
2009/10 Mark Gross Resident Research Award
2010 RD2010 Travel Award
2010 AUPO/Heed Resident Retreat
2011 Gragoudas Award, Macula Society
2012 Heed Fellowship Award
2012 Michels’ Foundation Fellowship Award
Dr. Mark E Kleinman, Lexington KY - MD (Doctor of Medicine)
Dr. Mark E Kleinman, Lexington KY - MD (Doctor of Medicine)
Specialties:
Ophthalmology
Age:
47
Address:
740 S Limestone St, Lexington 40536
(859) 323-5867 (Phone)
(859) 323-5867 (Phone)
Procedures:
Repair Of Retinal Detachment, Retinal Laser Surgery, Vitrectomy
Conditions:
Age-Related Macular Degeneration, Diabetic Retinopathy, Retina Disease, Retinal Detachment
Languages:
English, Spanish
Hospitals:
740 S Limestone St, Lexington 40536
University of Kentucky Hospital
800 Rose St, Lexington 40536
University of Kentucky Hospital
800 Rose St, Lexington 40536
Education:
Internship Hospital
Nyu School Of Medicine
Graduated: 2006
University Of Kentucky College Of Medicine
Graduated: 2011
Graduated: 2013
Emory University
Graduated: 1998
Nyu School Of Medicine
Graduated: 2006
University Of Kentucky College Of Medicine
Graduated: 2011
Graduated: 2013
Emory University
Graduated: 1998
Mark Kleinman, Lexington KY
Mark Kleinman, Lexington KY
Work:
UK Dept of Ophthalmology
740 S Limestone St, Lexington, KY 40536
740 S Limestone St, Lexington, KY 40536
Mark Ellsworth Kleinman, Lexington KY
Mark Ellsworth Kleinman, Lexington KY
Specialties:
Ophthalmologist
Address:
740 S Limestone St, Lexington, KY 40536
Ccr3 And Its Ligands Are Therapeutic And Diagnostic Targets For Neovascular Age-Related Macular Degeneration
Ccr3 And Its Ligands Are Therapeutic And Diagnostic Targets For Neovascular Age-Related Macular Degeneration
US Patent:
2012006, Mar 15, 2012
Filed:
May 26, 2010
Appl. No.:
13/322087
Inventors:
Jayakrishna Ambati - Lexington KY, US
Mark Ellsworth Kleinman - Lexington KY, US
Mark Ellsworth Kleinman - Lexington KY, US
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61K 49/00, A61K 38/02, A61P 27/02, G01N 33/566, A61K 39/395, B82Y 15/00
US Classification:
424 96, 435 721, 4241721, 514 208, 4241781, 977774, 977927
Abstract:
The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither eosinophils nor mast cells are present in human CNV. The genetic or pharmacological targeting of CCR3 or eotaxins as disclosed herein inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation as it occurred in mice lacking eosinophils or mast cells and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing CNV than vascular endothelial growth factor-A (VEGF-A) neutralization, which is currently in clinical use, and, unlike VEGF-A blockade, not toxic to the mouse retina. In vivo imaging with CCR3-targeting quantum dots located spontaneous CNV invisible to standard fluorescein angiography in mice before retinal invasion. CCR3 targeting is useful in reducing vision loss due to AMD through early detection and therapeutic angioinhibition.