Mark Damon Butler
Physician at Double Eagle Way, Flagstaff, AZ

6471687, Oct 29, 2002

Nov 30, 1998

09/201173

Mark D. Butler - Flagstaff AZ
Daniel F. Davidson - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Enterprise Holdings, Inc. - Newark DE

A61K 922

6048911, 156292, 1565831

This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

6426214, Jul 30, 2002

Nov 8, 1999

09/435510

Mark D. Butler - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Enterprise Holdings, Inc. - Newark DE

C12M 300

4352891, 424 937, 424423, 435 703, 435 711, 435 712, 435177, 435180, 435182, 435382, 435395, 435401, 435402, 435403

Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. A preferred device contains a polytetrafluoroethylene permeable membrane and a flexible polymer core having a plurality of ridges and valleys running lengthwise along the core. The cell zone may contain support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.

5980889, Nov 9, 1999

Aug 5, 1997

8/906367

Mark D. Butler - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flafstaff AZ

A01N 6300, C12P 2104, C12N 1104, C12N 500

424 937

Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.

5787900, Aug 4, 1998

Oct 11, 1996

8/731353

Mark D. Butler - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flagstaff AZ

A61B 1900

128898

This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

5913998, Jun 22, 1999

Jan 9, 1997

8/781119

Mark D. Butler - Flagstaff AZ
Daniel F. Davidson - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flagstaff AZ

A61F 202, A61M 3100, B32B 3104

156245

This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

5626561, May 6, 1997

Jun 7, 1995

8/479932

Mark D. Butler - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flagstaff AZ

A61M 3100

604 49

This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

5843069, Dec 1, 1998

Jul 10, 1997

8/891119

Mark D. Butler - Flagstaff AZ
Daniel F. Davidson - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ
James W. Moore - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flagstaff AZ

A61K 922

6048911

This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

5902745, May 11, 1999

May 21, 1997

8/859946

Mark D. Butler - Flagstaff AZ
Paul D. Drumheller - Flagstaff AZ
Stanley L. Mish - Flagstaff AZ

Gore Hybrid Technologies, Inc. - Flagstaff AZ

C12M3/06

4352972

The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.

6031148, Feb 29, 2000

Apr 2, 1993

8/042293

Byron Kent Hayes - Flagstaff AZ
William R. Hardwick - Flagstaff AZ
Charles F. White - Camp Verde AZ
Mark D. Butler - Flagstaff AZ

W. L. Gore & Associates, Inc. - Newark DE

A61F 202, A61F 206, A61F 204, A61B 1708

623 11

An implantable bioabsorbable article for the separation and regeneration of tissue at a tissue defect site in the form of a fibrous matrix laminarly affixed to both surfaces of a cell-barrier sheet material. When implanted it allows ingrowth of tissue into the fibrous matrix side of the material; simultaneously the tissue to be regenerated at the tissue defect site is separated from the ingrowing tissue by the cell-barrier sheet material. A method for making the implantable bioabsorbable article is also described.