MARK COOPER, MD
Osteopathic Medicine at Metrohealth Dr, Cleveland, OH

6339065, Jan 15, 2002

Jan 30, 1996

08/594299

Mark J. Cooper - Solon OH

Case Western Reserve University - Cleveland OH

A61K 3170

514 44, 435 691, 435455

Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. In conjunction with liposomal or receptor-mediated delivery systems, papovavirus-derived episomal plasmids provide an alternative vector for gene therapy, particularly when utilizing strategies requiring high levels of gene expression.

6506890, Jan 14, 2003

Nov 28, 2000

09/722340

Mark J. Cooper - Solon OH 44139
Tomasz H. Kowalczyk - University Heights OH 44118
Murali Krishna Pasumarthy - Willoughby Hills OH 44092

C07H 2102

536 231, 536 221, 435 6, 435 71, 435 911, 435 912

An automated nucleic acid compaction device for analyzing and compacting a nucleic acid complex into unimolecular nucleic acid particles. Broadly, the device includes a container support and agitation system; a measuring and testing system; and a dispensing system; all controlled by a control system. The control system controls the support and agitation system and the dispensing system based either on a predetermined formulation or by analysis of feedback data provided by the measuring and testing system. In a preferred embodiment, the device is a real-time measuring and mixing instrument operating in a closed loop system. The preferred embodiment also comprises a monitoring system including a submersible probe which is positioned in the batch solution to provide data to a controller. Once a desired level of nucleic acid compaction is reached, as detected by the monitoring system, the controller stops the dispensing and mixing agitating systems.

6281005, Aug 28, 2001

May 14, 1999

9/311553

Hector L. Casal - Shaker Heights OH
Mark J. Cooper - Solon OH
Tomasz H. Kowalczyk - University Heights OH
Murali Krishna Pasumarthy - Willoughby Hills OH
Jose C. Perales - Barcelona, ES
Steven J. Torontali - Moreland Hills OH

Copernicus Therapeutics, Inc. - Cleveland OH

C12M 134, C12Q 168, C07H 1900, A61K 4800, G01N 1502

4352872

An automated nucleic acid compaction device for analyzing and compacting a nucleic acid complex into unimolecular nucleic acid particles. Broadly, the device includes a container support and agitation system; a measuring and testing system; and a dispensing system; all controlled by a control system. The control system controls the support and agitation system and the dispensing system based either on a predetermined formulation or by analysis of feedback data provided by the measuring and testing system. In a preferred embodiment, the device is a real-time measuring and mixing instrument operating in a closed loop system. The preferred embodiment also comprises a monitoring system including a submersible probe which is positioned in the batch solution to provide data to a controller. Once a desired level of nucleic acid compaction is reached, as detected by the monitoring system, the controller stops the dispensing and mixing agitating systems.

5624820, Apr 29, 1997

Jun 7, 1995

8/479204

Mark J. Cooper - Solon OH

Case Western Reserve University - Cleveland OH

C12P 2106, C12N 1537, C12N 1585

435 691

Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. In conjunction with liposomal or receptor-mediated delivery systems, papovavirus-derived episomal plasmids provide an alternative vector for gene therapy, particularly when utilizing strategies requiring high levels of gene expression.

5770374, Jun 23, 1998

Oct 10, 1996

8/728608

Mark J. Cooper - Solon OH

Case Western Reserve University - Cleveland OH

C12Q 168

435 6

Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. Candidate oncogenes and anti-oncogenes can be identified by transfecting the episomal plasmids containing a candidate oncogene or anti-oncogene into non-tumorigenic cells and screening for a tumorigenic phenotype.