Inventors:
Martin Pomper - Baltimore MD, US
John Musachio - Baltimore MD, US
Hong Fan - Lutherville Timonium MD, US
Robert Dannals - Sparks MD, US
Catherine Foss - Baltimore MD, US
Eifion Phillips - Wilmington DE, US
John Gordon - Wilmington DE, US
Dennis McCarthy - Wilmington DE, US
Richard Keith - Wilmington DE, US
Mark Smith - Wilmington DE, US
Richard Heys - Wilmington DE, US
Peter Dorff - Wilmington DE, US
International Classification:
A61K051/00, A61K031/4747, C07D491/14, C07F005/00
US Classification:
424001110, 514278000, 534011000, 546018000
Abstract:
The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the a7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express a7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.