Inventors:
Jon Y. Takemoto - North Logan UT
John R. Forney - Wrair Washington DC
Mark C. Healey - Utah State University UT
Shiguang Yang - Logan UT
Karl A. Werbovetz - Montgomery Village MD
Assignee:
Utah State University - Logan UT
International Classification:
A01N 3718, A61K 3800
Abstract:
A method for controlling infections caused by protozoans, such as Cryptosporidium parvum, Plasmodium falciparum, and Leishmania donovani. The method comprises using syringomycin-family lipodepsipeptides, preferably syringomycins such as syringomycin E, to control or prevent infections caused by protozoans. The method is directed to therapeutic treatment of mammals, such as humans, exposed to protozoans, and additionally as a prophylactic treatment in immunocompromised subjects at high risk for contracting protozoan infections.