Inventors:
Vincent Wingate - Chapel HIll NC
Mark Wolff - Cary NC
Assignee:
Rhone -Poulenc AG Company - Research Triangle Park NC
International Classification:
C07K 14705, C12N 510, C12N 1512
Abstract:
The present invention provides isolated nucleic acids encoding lepidopteran gamma aminobutyric acid (GABA) gated chloride channels. In a preferred embodiment, the nucleic acids encoding lepidopteran GABA gated chloride channels are isolatable from Heliothis virescens. The invention further provides recombinant lepidopteran GABA gated chloride channels and methods for identifying agonists and antagonists to a lepidopteran GABA gated chloride channels.