Inventors:
Jill D. Jacobson - Kansas City MO, US
Mark Clements - Kansas City MO, US
Assignee:
THE CHILDREN'S MERCY HOSPITAL - Kansas City MO
International Classification:
A61K 38/25, C12Q 1/68, A61P 5/06
Abstract:
The present invention is directed towards a diagnostic test, treatment, and monitoring of treatment for growth hormone abnormalities including Growth Hormone Deficiency (“GHD”) as well as a kit comprising the necessary components of the present invention. G-protein expression and levels of mRNA are evaluated to determine if a patient has GHD or if treatment for GHD is effective. A G-protein agonist or antagonist is used to treat GHD by bringing G-protein expression and levels of mRNA into the normal range.