MARION WOODS WANNAMAKER
Pilots at Long Hl Rd, Bolton, MA
License number
Massachusetts A3842577
Issued Date
Sep 2015
Expiration Date
Sep 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
213 Long Hill Rd, Bolton, MA 01740
Professional information
Substituted N-(Pyrazol-5-Yl)-Pyrrolo[3,2-D]Pyrimidin-4-Amine Useful As Protein Kinase Inhibitors
US Patent:
8524720, Sep 3, 2013
Filed:
Jan 4, 2010
Appl. No.:
12/651639
Inventors:
David Bebbington - Newbury, GB
Hayley Binch - Encinitas CA, US
Ronald Knegtel - Abindgon, GB
Julian M.C. Golec - Woolstone, GB
Sanjay Patel - Abingdon, GB
Jean-Damien Charrier - Grove, GB
David Kay - Purton, GB
Robert Davies - Watertown MA, US
Pan Li - Lexington MA, US
Marion Wannamaker - Bolton MA, US
Cornelia Forster - Pelham MA, US
Albert Pierce - Cambridge MA, US
Hayley Binch - Encinitas CA, US
Ronald Knegtel - Abindgon, GB
Julian M.C. Golec - Woolstone, GB
Sanjay Patel - Abingdon, GB
Jean-Damien Charrier - Grove, GB
David Kay - Purton, GB
Robert Davies - Watertown MA, US
Pan Li - Lexington MA, US
Marion Wannamaker - Bolton MA, US
Cornelia Forster - Pelham MA, US
Albert Pierce - Cambridge MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 487/04, A61K 31/519, A61P 35/00, A61P 25/28, A61P 3/10
US Classification:
5142651, 544280
Abstract:
This invention describes novel pyrazole compounds of formula IV:.
Compounds Useful As Inhibitors Of Janus Kinases
US Patent:
2012015, Jun 21, 2012
Filed:
Oct 25, 2011
Appl. No.:
13/280670
Inventors:
Marion W. Wannamaker - Bolton MA, US
Francesco Salituro - Marlborough MA, US
Albert Pierce - Cambridge MA, US
Alex Aronov - Newton MA, US
Jian Wang - Newton MA, US
Luc Farmer - Foxboro MA, US
Mark Ledeboer - Acton MA, US
Tiansheng Wang - Concord MA, US
Randy Bethiel - Lexington MA, US
Brian Ledford - Attleboro MA, US
Emilie Porter Huck - Sudbury MA, US
Francesco Salituro - Marlborough MA, US
Albert Pierce - Cambridge MA, US
Alex Aronov - Newton MA, US
Jian Wang - Newton MA, US
Luc Farmer - Foxboro MA, US
Mark Ledeboer - Acton MA, US
Tiansheng Wang - Concord MA, US
Randy Bethiel - Lexington MA, US
Brian Ledford - Attleboro MA, US
Emilie Porter Huck - Sudbury MA, US
International Classification:
A61K 31/506, C07D 403/04, C07D 413/14, A61K 31/5377, C07D 403/10, C12N 9/99, A61P 9/00, A61P 25/28, A61P 37/00, A61P 37/06, A61P 29/00, C07D 401/04, A61P 35/00
US Classification:
51421018, 544328, 514256, 544324, 514275, 544122, 5142362, 544295, 514249, 435184
Abstract:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Compounds Useful As Inhibitors Of Janus Kinases
US Patent:
2010016, Jun 24, 2010
Filed:
Sep 22, 2009
Appl. No.:
12/564156
Inventors:
Marion W. Wannamaker - Bolton MA, US
Francesco Salituro - Marlborough MA, US
Albert Pierce - Cambridge MA, US
Alex Aronov - Newton MA, US
Jian Wang - Newton MA, US
Luc Farmer - Foxboro MA, US
Mark Ledeboer - Acton MA, US
Tiansheng Wang - Concord MA, US
Randy Bethiel - Lexington MA, US
Brian Ledford - Attleboro MA, US
Emilie Porter Huck - Sudbury MA, US
Francesco Salituro - Marlborough MA, US
Albert Pierce - Cambridge MA, US
Alex Aronov - Newton MA, US
Jian Wang - Newton MA, US
Luc Farmer - Foxboro MA, US
Mark Ledeboer - Acton MA, US
Tiansheng Wang - Concord MA, US
Randy Bethiel - Lexington MA, US
Brian Ledford - Attleboro MA, US
Emilie Porter Huck - Sudbury MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 31/506, C07D 401/04, C07D 403/04, C07D 417/10, C07D 403/10, C07D 405/10, A61P 35/00, A61P 9/00, A61P 19/08, A61P 37/06, A61P 29/00, A61P 37/00, A61P 31/12, C12N 5/00
US Classification:
51421018, 544328, 514256, 544324, 514275, 544327, 544295, 514249, 435375
Abstract:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Deazapurines Useful As Inhibitors Of Janus Kinases
US Patent:
2009022, Sep 10, 2009
Filed:
Oct 3, 2008
Appl. No.:
12/245069
Inventors:
Mark Ledeboer - Acton MA, US
David Messersmith - Somerville MA, US
Francois Maltais - Tewksbury MA, US
Huai Gao - Arlington MA, US
Tiansheng Wang - Concord MA, US
Jingrong Cao - Newton MA, US
John Duffy - Northborough MA, US
Cornelia Forster - Pelham NH, US
Marion Wannamaker - Bolton MA, US
Francesco Salituro - Marlboro MA, US
Albert Pierce - Cambridge MA, US
Luc Farmer - Foxboro MA, US
Valerie Marone - Cambridge MA, US
David Messersmith - Somerville MA, US
Francois Maltais - Tewksbury MA, US
Huai Gao - Arlington MA, US
Tiansheng Wang - Concord MA, US
Jingrong Cao - Newton MA, US
John Duffy - Northborough MA, US
Cornelia Forster - Pelham NH, US
Marion Wannamaker - Bolton MA, US
Francesco Salituro - Marlboro MA, US
Albert Pierce - Cambridge MA, US
Luc Farmer - Foxboro MA, US
Valerie Marone - Cambridge MA, US
International Classification:
A61K 31/519, C07D 487/04, C12N 9/99
US Classification:
5142651, 544280, 435184
Abstract:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Prodrug Of An Ice Inhibitor
US Patent:
8329662, Dec 11, 2012
Filed:
Aug 16, 2011
Appl. No.:
13/210712
Inventors:
Marion W. Wannamaker - Bolton MA, US
Robert J. Davies - Watertown MA, US
Robert J. Davies - Watertown MA, US
Assignee:
Vertexd Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 38/05
US Classification:
514 2191, 514 201
Abstract:
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.
Deazapurines Useful As Inhibitors Of Janus Kinases
US Patent:
2009008, Apr 2, 2009
Filed:
Apr 5, 2007
Appl. No.:
11/732845
Inventors:
Mark Ledeboer - Acton MA, US
David Messersmith - Somerville MA, US
Francois Maltais - Tewksbury MA, US
Huai Gao - Lincoln MA, US
Tiansheng Wang - Concord MA, US
Jingrong Cao - Newton MA, US
John Duffy - Northborough MA, US
Cornelia Forster - Pelham NH, US
Marion Wannamaker - Bolton MA, US
Francesco Salituro - Marlboro MA, US
Albert Pierce - Cambridge MA, US
Luc Farmer - Foxboro MA, US
Valerie Marone - Cambridge MA, US
David Messersmith - Somerville MA, US
Francois Maltais - Tewksbury MA, US
Huai Gao - Lincoln MA, US
Tiansheng Wang - Concord MA, US
Jingrong Cao - Newton MA, US
John Duffy - Northborough MA, US
Cornelia Forster - Pelham NH, US
Marion Wannamaker - Bolton MA, US
Francesco Salituro - Marlboro MA, US
Albert Pierce - Cambridge MA, US
Luc Farmer - Foxboro MA, US
Valerie Marone - Cambridge MA, US
International Classification:
A61K 31/519, C07D 487/04
US Classification:
5142651, 544280
Abstract:
The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Prodrug Of An Ice Inhibitor
US Patent:
8022041, Sep 20, 2011
Filed:
Jul 1, 2008
Appl. No.:
12/165838
Inventors:
Marion W. Wannamaker - Bolton MA, US
Robert J. Davies - Watertown MA, US
Robert J. Davies - Watertown MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07K 5/06
US Classification:
514 2191, 530331, 549200, 549263
Abstract:
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.
Compositions Useful As Inhibitors Of Gsk-3
US Patent:
7491730, Feb 17, 2009
Filed:
Aug 1, 2003
Appl. No.:
10/632340
Inventors:
Cornelia J. Forster - Pelham NH, US
Larry C. Park - Waltham MA, US
Marion W. Wannamaker - Bolton MA, US
Larry C. Park - Waltham MA, US
Marion W. Wannamaker - Bolton MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 403/12, C07D 403/14, C07D 417/14, A61K 31/4162, A61K 31/506, A61K 31/5377, A61P 3/10, A61P 9/10, A61P 25/18
US Classification:
514275, 5142345, 51425218, 514256, 544328, 544122, 544 60, 544295
Abstract:
The present invention provides a compound of formula I:.
Prodrug Of An Ice Inhibitor
US Patent:
7417029, Aug 26, 2008
Filed:
May 18, 2001
Appl. No.:
09/860750
Inventors:
Marion W Wannamaker - Bolton MA, US
Robert J Davies - Somerville MA, US
Robert J Davies - Somerville MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07K 5/06
US Classification:
514 19, 514 18, 530331, 549200, 549263
Abstract:
This invention describes an ICE inhibitor prodrug (I) having good bioavailability.
Compositions Useful As Inhibitors Of Gsk-3
US Patent:
7872129, Jan 18, 2011
Filed:
Dec 18, 2008
Appl. No.:
12/338129
Inventors:
Cornelia J. Forster - Pelham NH, US
Larry C. Park - Waltham MA, US
Marion W. Wannamaker - Bolton MA, US
Larry C. Park - Waltham MA, US
Marion W. Wannamaker - Bolton MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 403/12, C07D 403/14, C07D 417/14, A61K 31/4162, A61K 31/506, A61K 31/5377, A61P 3/10, A61P 9/10, A61P 25/18
US Classification:
544328, 544122, 514256, 514275, 5142345, 51425218
Abstract:
The present invention provides a compound of formula I:.