MARIA R ABRAHAM, M.D.
Osteopathic Medicine at Eastern Ave, Baltimore, MD
License number
Maryland D60471
Category
Osteopathic Medicine
Type
Cardiovascular Disease
Address
Address
4940 Eastern Ave, Baltimore, MD 21224
Phone
(410) 550-4642
(410) 502-0550
(410) 502-0550
Personal information
See more information about MARIA R ABRAHAM at radaris.comName
Address
Phone
119 Overhill Rd, Baltimore, MD 21210
21107 Silver Birch Ln, Germantown, MD 20876
35 Travis Ct, Gaithersburg, MD 20879
35 Travis Ct, Gaithersburg, MD 20879
21107 Silver Birch Ln, Germantown, MD 20876
Professional information
Dr. Maria R Abraham, Baltimore MD - MD (Doctor of Medicine)
Specialties:
Cardiology
Address:
4940 Eastern Ave, Baltimore 21224
(410) 550-4642 (Phone)
JOHNS HOPKINS MEDICAL INSTITUTE
720 Rutland Ave, Baltimore 21205
(800) 777-7902 (Phone), (410) 955-9677 (Fax)
(410) 550-4642 (Phone)
JOHNS HOPKINS MEDICAL INSTITUTE
720 Rutland Ave, Baltimore 21205
(800) 777-7902 (Phone), (410) 955-9677 (Fax)
Procedures:
Cardiac Catheterization (incl. Coronary Angiography), Cardiac Imaging, Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest, Cardioverter-Defibrillator or Pacemaker Insertion, Removal or Repair, Chest CT (incl. Heart and Lungs)
Conditions:
Angina and Acute Coronary Syndrome, Aortic Valve Disease, Arrhythmias (incl. Atrial Fibrillation), Cardiomegaly, Cardiomyopathy, Carotid Artery Disease, Congenital Heart Disease, Congestive Heart Failure, Coronary Artery Disease (CAD), Heart Attack (Acute Myocardial Infarction), Hyperlipidemia, Hypertension, Hypertensive Heart and Chronic Kidney Disease, Hypotension, Mitral Valve Disease, Pericardial Disease, Pulmonary Hypertension, Septal Defect, Syncope, Tricuspid Valve Disease
Languages:
English
Hospitals:
4940 Eastern Ave, Baltimore 21224
JOHNS HOPKINS MEDICAL INSTITUTE
720 Rutland Ave, Baltimore 21205
Johns Hopkins Bayview Medical Center
4940 Eastern Ave, Baltimore 21224
JOHNS HOPKINS MEDICAL INSTITUTE
720 Rutland Ave, Baltimore 21205
Johns Hopkins Bayview Medical Center
4940 Eastern Ave, Baltimore 21224
Education:
Medical School
Goa Medical College, Goa University
Graduated: 1992
Wake Forest Baptist Med Center
Graduated: 1996
Sthwstrn Med Center
Graduated: 1998
Mayo Clinic Rochester
Graduated: 2002
Goa Medical College, Goa University
Graduated: 1992
Wake Forest Baptist Med Center
Graduated: 1996
Sthwstrn Med Center
Graduated: 1998
Mayo Clinic Rochester
Graduated: 2002
Preventing Arrhythmias Associated With Cell Transplantation
US Patent:
2008026, Oct 23, 2008
Filed:
Mar 22, 2005
Appl. No.:
10/593814
Inventors:
Eduardo Marban - Beverly Hills CA, US
Maria Roselle Abraham - Baltimore MD, US
Maria Roselle Abraham - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 48/00, G01N 33/483, C12N 5/10, G01N 27/26
US Classification:
424 9321, 20440301, 205792, 435375
Abstract:
Skeletal myoblasts are an attractive cell type for transplantation since they are autologous and resistant to ischemia. However, clinical trials of myoblasts transplantation in heart failure have been plagued by ventricular tachy-arrhythmias and sudden cardiac death. The pathogenesis of these arrhythmias is poorly understood, but may be related to the fact that skeletal muscle cells, unlike heart cells, are electrically isolated by the absence of gap junctions. An in vitro model of myoblasts transplantation into cardiomyocyte monolayers can be used to investigate the mechanisms of transplant-associated arrhythmias. Co-cultures of human skeletal myoblasts and rat cardiomyocytes result in reentrant arrhythmias (spiral waves) that reproduce the features of ventricular tachycardia seen in patients receiving myoblasts transplants. These arrhythmias can be terminated by nitrendipine, an L-type calcium channel Mocker, but not by the Na channel blocker lidocaine. Genetic modification of myoblasts to stably express the gap junction protein connexin 43 decreases arrhythmogenicity in co-cultures. It similarly can be used to increase the safety of myoblasts transplantation in patients.
Maria R Abraham, Baltimore MD
Specialties:
Cardiologist
Address:
720 Rutland Ave, Baltimore, MD 21205
4940 Eastern Ave, Baltimore, MD 21224
4940 Eastern Ave, Baltimore, MD 21224
Education:
Goa Medical College-Madras University, Goa - Doctor of Medicine
The Mayo Clinic - Fellowship - Cardiovascular Disease (Internal Medicine)
The Mayo Clinic - Fellowship - Cardiovascular Disease (Internal Medicine)
Board certifications:
American Board of Internal Medicine Sub-certificate in Cardiovascular Disease (Internal Medicine)
Cardiac Stem Cells
US Patent:
2010006, Mar 18, 2010
Filed:
Nov 19, 2009
Appl. No.:
12/622106
Inventors:
Eduardo Marban - Beverly Hills CA, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12N 5/071
US Classification:
435381
Abstract:
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.
Cardiac Stem Cells
US Patent:
2010006, Mar 11, 2010
Filed:
Nov 19, 2009
Appl. No.:
12/622143
Inventors:
Eduardo Marban - Beverly Hills CA, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 35/12, A61P 9/00
US Classification:
424 937
Abstract:
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.
Cardiac Stem Cells
US Patent:
2008026, Oct 30, 2008
Filed:
Nov 8, 2005
Appl. No.:
11/666685
Inventors:
Eduardo Marban - Beverly Hills CA, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Maria Roselle Abraham - Baltimore MD, US
Rachel R. Smith - Baltimore MD, US
Assignee:
Johns Hopkins University - Baltimore MD
International Classification:
A61K 45/00, C12N 5/06, C12N 5/08, A61P 9/02
US Classification:
424 937, 435380, 435378, 435374, 435366
Abstract:
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.