Inventors:
Jayne RAPER - Carmel NY, US
Russell THOMPSON - New York NY, US
Marie SAMANOVIC - New York NY, US
Maria Del Pilar Molina PORTELA - New York NY, US
Assignee:
NEW YORK UNIVERSITY - New York NY
International Classification:
A01K 67/027, A01K 67/00, C12N 15/873, C12N 5/10
US Classification:
800 15, 800 13, 800 14, 800 18, 800 16, 800 17, 800 21, 435325
Abstract:
The present invention is directed to a Trypanosome-resistant, non-human transgenic animal whose somatic and germ cells comprise a nucleic acid which encodes an apolipoprotein L-I polypeptide (apoL-I). The apoL-I protein has the amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5. The first nucleic acid transgene is operatively associated with at least one expression regulatory sequence. Methods of producing and raising such transgenic animals as well as transgenic eggs and sperm are also disclosed.