Inventors:
Nicholas Stephen Bodor - Gainesville FL, US
Maria Grant - Gainesville FL, US
Assignee:
University of Florida - Gainesville FL
International Classification:
A61K 38/00, C07K 2/00, C07K 5/00
US Classification:
514 11, 514 2, 514 9, 514 15, 514 16, 514 17, 530300, 530317, 530324, 530409
Abstract:
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridine⇄pyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.