MARIA ANN CROYLE
Pharmacy in Austin, TX
License number
Pennsylvania RP038932L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
Austin, TX 78704
Pennsylvania
Pennsylvania
Personal information
See more information about MARIA ANN CROYLE at radaris.comName
Address
Phone
11008 Jollyville Rd APT 232, Austin, TX 78759
2622 Wheeling Ave, El Paso, TX 79930
El Paso, TX
3613 Breckenridge Dr, El Paso, TX 79936
2326 County Road 655, Farmersville, TX 75442
Professional information
Maria Croyle
Location:
Austin, Texas Area
Industry:
Biotechnology
Methods For Rapid Peg-Modification Of Viral Vectors, Compositions For Enhanced Gene Transduction, Compositions With Enhanced Physical Stability, And Uses Therefor
US Patent:
6399385, Jun 4, 2002
Filed:
Sep 27, 2000
Appl. No.:
09/670277
Inventors:
Maria Croyle - Austin TX
James M. Wilson - Gladwyne PA
James M. Wilson - Gladwyne PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15861
US Classification:
435456, 4353201, 435455, 435457, 4352351, 435243, 435247, 435250, 435260, 424 932, 424 931, 424 936
Abstract:
A rapid method for modifying a viral capsid or envelope protein with a polyethylene glycol (PEG) is described. Also provided are methods of delivering a molecule using the PEG-modified viruses of the invention. Compositions containing the PEG-modified viruses of the invention, are characterized by improved gene expression, reduced neutralizing antibody and CTL production. Also provided are viral compositions having enhanced physical stability, in which the viruses are lyophilized in a formulation having a 1:1 ratio of sucrose and mannitol are provided.