Inventors:
William Wold - Chesterfield MO, US
Karoly Toth - St. Louis MO, US
Maria Thomas - Crestwood MO, US
International Classification:
C12N015/861, A61K049/00, C12Q001/70
US Classification:
424009200, 435456000, 435005000
Abstract:
The present invention relates to the use of cotton rats and Syrian hamsters as models for adenoviral gene therapy. In particular, the models are directed to the examination of the ability of various replicative, non-replicative and conditionally-replicative adenovirus vectors to treat cancer.