Inventors:
Randa A. El-Zein - League City TX, US
Matthew B. Schabath - Houston TX, US
Carol J. Etzel - Houston TX, US
Mirtha S. Lopez - Porter TX, US
Margaret R. Spitz - Houston TX, US
Assignee:
The Board of Regents, of the University of Texas System - Austin TX
International Classification:
C12Q 1/68
Abstract:
The present invention demonstrates the differential sensitivity of PBLs from lung cancer patients and healthy controls to NNK-induced genetic damage. The data provide convincing evidence that the preferred CBMN assay is a robust test for detection of this sensitivity and yields results that are a good predictor of, for example, lung cancer risk. The simplicity, rapidity, and sensitivity of the CBMN test make it a valuable tool for screening and, for example, prioritizing potential cases for early detection of the disease.