Inventors:
Russell M. Medford - Atlanta GA
Margaret K. Offermann - Atlanta GA
R. Wayne Alexander - Atlanta GA
Sampath Parthasarathy - Atlanta GA
Assignee:
Emory University - Atlanta GA
International Classification:
A61K 3140, A61K 3154, A61K 31265, A61K 31185
Abstract:
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.