Inventors:
Margaret Han Dugan - Woodside NY, US
International Classification:
A61K 31/502, C07D 401/06, C07D 487/04, A61K 31/33
US Classification:
514248, 544237, 544179, 514183
Abstract:
The invention relates to a pharmaceutical combination which comprises (a) a vasculostatic compound, (b) an alkylating agent and (c) optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use for the treatment of a tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a tumor disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.