MARGARET ANN LIU
Medical Practice in Lafayette, CA
License number
Pennsylvania MD044203E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Lafayette, CA 94549
Pennsylvania
Pennsylvania
Professional information
Synthetic Hepatitis C Genes
US Patent:
6653125, Nov 25, 2003
Filed:
Feb 17, 2000
Appl. No.:
09/194949
Inventors:
John J. Donnelly - Moraga CA
Margaret A. Liu - Lafayette CA
John W. Shiver - Doylestown PA
Tong-Ming Fu - Lansdale PA
Margaret A. Liu - Lafayette CA
John W. Shiver - Doylestown PA
Tong-Ming Fu - Lansdale PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C12N 1579
US Classification:
4353201, 536 2372
Abstract:
The present invention relates to polynucleotides comprising a DNA sequence encoding an HCV protein and fragments thereof that contain codons optimized for expression in a vertebrate host. Uses of the polynucleotides include eliciting an immune response specifically recognizing HCV.
Synthetic Hepatitis C Genes
US Patent:
2005007, Apr 7, 2005
Filed:
Sep 17, 2003
Appl. No.:
10/664391
Inventors:
John Donnelly - Moraga CA, US
Margaret Liu - Lafayette CA, US
John Shiver - Chalfont PA, US
Tong-Ming Fu - Ambler PA, US
Margaret Liu - Lafayette CA, US
John Shiver - Chalfont PA, US
Tong-Ming Fu - Ambler PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12Q001/70, C07H021/04, C12N007/01, C07K014/02, C12N015/86
US Classification:
435005000, 435069300, 435235100, 435456000, 435325000, 530350000, 536023720
Abstract:
This invention relates to novel formulations of pharmaceutical products, specifically nucleic acid vaccine products. The nucleic acid vaccine products, when introduced directly into muscle cells, induce the production of immune responses which specifically recognize Hepatitis C virus (HCV).