MARC S KARETNY
Pharmacy in Philadelphia, PA
License number
Pennsylvania PI087522L
Category
Pharmacy
Type
Pharmacy Intern
Address
Address
Philadelphia, PA 19116
Professional information
Hydrolyzed Cellulose Granulations For Pharmaceuticals
US Patent:
5858409, Jan 12, 1999
Filed:
Apr 17, 1996
Appl. No.:
8/785228
Inventors:
Marc S. Karetny - Philadelphia PA
David F. Erkoboni - Lawrenceville NJ
Ronald S. Vladyka - Somerset NJ
Howard J. Stamato - Bridgewater NJ
David F. Erkoboni - Lawrenceville NJ
Ronald S. Vladyka - Somerset NJ
Howard J. Stamato - Bridgewater NJ
Assignee:
FMC Corporation - Philadelphia PA
International Classification:
A61K 914
US Classification:
424489
Abstract:
The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets compressed from such granules. In these formulations there is employed from 1 to 97% by weight pharmaceutical active, from about 3 to 99% by weight hydrolyzed cellulose, based on the dry weight of the granulation, and optionally conventional granulation and/or tableting additives such as surfactants, disintegrants and antiadherents/flow aids.