Inventors:
David Goldman - Potomac MD, US
Nakao Iwata - Showa-ku, JP
Marc Schuckit - Del Mar CA, US
International Classification:
C12Q001/68, C07H021/04, C12P021/02, C12N005/06, C07K014/705
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:
Compositions and methods based on a polymorphism in the gene encoding the 6 subunit of the human GABAneurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the 6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.