Inventors:
Ulf Eriksson - Stockholm, SE
Daniel Lawrence - Ann Arbor MD, US
Enming Joe Su - Ann Arbor MD, US
Dudley Strickland - Brookville MD, US
Manuel Yepes - Atlanta GA, US
Linda Fredriksson - Stockholm, SE
Assignee:
LUDWIG INSTITUTE FOR CANCER RESEARCH - New York NY
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MD
UNIVERSITY OF MARYLAND, BALTIMORE - Baltimore MD
International Classification:
A61K 31/4439, A61K 31/4412, A61K 31/4709, A61K 31/404, A61P 7/10, A61K 31/416, A61K 31/502, A61K 38/49, A61P 7/02, A61P 9/00, A61K 31/506, A61K 31/444
US Classification:
424 9464, 514338, 51425218, 514346, 51425219, 514313, 514414, 514333, 514407, 514248
Abstract:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.