Inventors:
Terry B. Strom - Brookline MA
Lauro Vasconcellos - Brookline MA
Manikkam Suthanthiran - New York NY
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
Beth Israel Deaconess Medical Center - Boston MA
International Classification:
C12Q 168
Abstract:
The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of two out of three immune activation marker genes perforin, granzyme B and Fas ligand, in a tissue biopsy or peripheral blood mononuclear cell sample, particularly using reverse transcription polymerase chain reaction; methods of assessing antirejection therapy; and kits for use in evaluating transplant rejection.