MALIHA ZAHID
Medical Practice in Gibsonia, PA
License number
Pennsylvania MD073221L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Gibsonia, PA 15044
Personal information
See more information about MALIHA ZAHID at radaris.comName
Address
Phone
1804 Wilderness Cir, Gibsonia, PA 15044
1804 Wilderness Cir, Gibsonia, PA 15044
200 Lothrop St, Pittsburgh, PA 15213
202 Briaridge, Pittsburgh, PA 15235
202 Briaridge Dr, Turtle Creek, PA 15145
Professional information
See more information about MALIHA ZAHID at trustoria.com
Cardiac-Specific Protein Targeting Domain
Cardiac-Specific Protein Targeting Domain
US Patent:
2012024, Sep 27, 2012
Filed:
Oct 14, 2011
Appl. No.:
13/273976
Inventors:
Paul David Robbins - Pittsburgh PA, US
Maliha Zahid - Gibsonia PA, US
Maliha Zahid - Gibsonia PA, US
International Classification:
A61K 38/10, C07K 14/52, C07K 14/475, C07K 9/00, C07K 7/08, C07K 7/06, A61K 38/14, A61K 38/08, A61K 38/18, A61K 38/19, C12N 5/077, A61K 38/43, A61K 38/47, A61P 3/00, A61K 38/44, A61P 3/06, A61P 9/00, A61P 9/10, A61P 9/06, C12N 9/96
US Classification:
424 943, 435188, 530399, 530322, 530327, 530328, 514 209, 514 215, 514 216, 514 217, 514 76, 435375, 514 81, 514 91, 514 95, 514 212
Abstract:
The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their derivatives to deliver peptides, proteins or nucleic acids specifically to the heart. It is based, at least in part, on the discovery that the peptide APWHLSSQYSRT (SEQ ID NO:1) functioned as a cardiac-specific protein targeting peptide and was successful in delivering a number of different cargoes to cardiac muscle cells in vitro and in vivo.