Inventors:
Patricia Denny - Los Angeles CA, US
Paul C. Denny - Los Angeles CA, US
Mahvash Navazesh - Los Angeles CA, US
Assignee:
Proactive Oral Solutions, Inc. - Long Beach CA
University of Southern California - Los Angeles CA
International Classification:
G01N 33/53, G01N 33/543
US Classification:
435 71, 436501, 436518, 436827, 435 734
Abstract:
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva with two or more lectins under conditions that allow the two or more lectins to bind to a lectin-binding component of the saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.