Inventors:
Prudence Talbot - Redondo Beach CA, US
Goar Melkonian - Riverside CA, US
Karen Riveles - Riverside CA, US
Lynn Ji - San Diego CA, US
International Classification:
A61K031/53, A61K031/501, A61K031/498, A61K031/519, A61K031/506, A61K031/444
US Classification:
514/242000, 514/247000, 514/252010, 514/255050, 514/256000, 514/259100, 514/336000, 514/345000, 514/352000
Abstract:
The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I
wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is or 1; R, R, and Rindependently represent hydrogen, a chemical bond, Calkyl; Calkenyl; Calkinyl; aryl; aryl-Calkyl; Cheterocyclyl; Cheteroaryl; halo, CF; NO; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R, R, and Rindependently represent hydrogen, Calkyl; Calkenyl; Calkinyl; aryl; aryl-Calkyl; Cheterocyclyl; Cheteroaryl; halo, CF; NO; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or Rand Rtogether form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or Calkyl; R* is hydrogen, or Calkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, Calkyl, halo, NO, Calkoxy, and CF3, or a pharmaceutically acceptable salt thereof.