Inventors:
Andrew I. Damokosh - West Hartford CT, US
Natalia Iartchouk - Wayland MA, US
Edwin A. Clark - Pennington NJ, US
Karen Lu - Houston TX, US
Lynn Hartmann - Rochester MN, US
Gordon B. Mills - Houston TX, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/68
US Classification:
435 6, 536 231, 536 235, 435 4
Abstract:
The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer.