Inventors:
Salah Zahr - Acton MA
David A. Swanson - Burlington MA
Adel M. Moussa - Burlington MA
Luning Han - Allston MA
Assignee:
Pharma-Eco Laboratories, Inc. - Devens MA
International Classification:
C07D41104
Abstract:
The present invention relates to a method of preparing enantiomers and diastereomers of a 2â²,3â²-dideoxy-5-fluoro-3â²thiocytadine (FTC) or a derivative thereof as represented by the following structural formula: In Structural Formula I, R is H, a substituted or unsubstituted organic acid radical, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaralkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstituted cycloalkylalkyl, a substituted or unsubstituted heterocycloalkylalkyl, a sugar or a protecting group.