LUKE WILLIAMS ASHCRAFT
Pilots at Carolina St, San Francisco, CA
License number
California A3935856
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
668 Carolina St, San Francisco, CA 94107
Professional information
Scientist At Cytokinetics
Position:
scientist at cytokinetics
Location:
San Francisco Bay Area
Industry:
Research
Work:
cytokinetics
-
scientist
Certain Amino-Pyridazines, Compositions Thereof, And Methods Of Their Use
US Patent:
2013014, Jun 6, 2013
Filed:
Apr 22, 2011
Appl. No.:
13/642207
Inventors:
Luke W. Ashcraft - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Scott Collibee - San Carlos CA, US
Chihyuan Chuang - Millbrae CA, US
Jeff Gardina - South San Francisco CA, US
Bradley P. Morgan - Moraga CA, US
Alex R. Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey M. Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
Pu-Ping Lu - Foster City CA, US
Antonio Romero - San Mateo CA, US
Gustave Bergnes - Pacifica CA, US
Scott Collibee - San Carlos CA, US
Chihyuan Chuang - Millbrae CA, US
Jeff Gardina - South San Francisco CA, US
Bradley P. Morgan - Moraga CA, US
Alex R. Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey M. Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
Pu-Ping Lu - Foster City CA, US
Antonio Romero - San Mateo CA, US
International Classification:
A61K 31/501, C07D 401/12, C07D 413/14, C07D 513/04, C07D 487/04, C07D 405/14, C07D 417/14, C07D 401/14, C07D 409/14, A61K 31/50, C07D 237/06, C07D 403/04
US Classification:
51421018, 5142102, 5142278, 5142365, 51425202, 51425203, 544 582, 544114, 544238
Abstract:
Provided are compounds of Formula I:or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
Certain Heterocycles, Compositions Thereof, And Methods For Their Use
US Patent:
2013006, Mar 7, 2013
Filed:
Sep 12, 2012
Appl. No.:
13/612715
Inventors:
Luke W. Ashcraft - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Chihyuan Chuang - Millbrae CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Bradley Morgan - Moraga CA, US
Alex Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
Gustave Bergnes - Pacifica CA, US
Chihyuan Chuang - Millbrae CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Bradley Morgan - Moraga CA, US
Alex Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
International Classification:
C07D 285/08, C07D 417/04, C07D 417/06, C07D 417/10, C07D 413/12, C07D 277/82, C07D 413/04, C07D 401/12, C07D 271/113, C07D 249/14, C07D 417/12, C07D 417/14
US Classification:
544134, 548128, 5462687, 546209, 544367, 548138, 546256, 544316, 548161, 5462701, 5462694, 5462724, 548143, 5482648, 5462697, 5462714, 5462754
Abstract:
Provided are compounds of Formula I:or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, X, Z, Z, Z, Zand m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
Certain Heterocycles, Compositions Thereof, And Methods For Their Use
US Patent:
2012028, Nov 15, 2012
Filed:
Apr 13, 2012
Appl. No.:
13/446432
Inventors:
Luke W. Ashcraft - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Chihyuan Chuang - Millbrae CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Bradley Morgan - Moraga CA, US
Alex Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
Gustave Bergnes - Pacifica CA, US
Chihyuan Chuang - Millbrae CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Bradley Morgan - Moraga CA, US
Alex Muci - San Francisco CA, US
Xiangping Qian - Foster City CA, US
Jeffrey Warrington - San Mateo CA, US
Zhe Yang - Daly City CA, US
International Classification:
C07D 417/12, C07D 417/04, C07D 417/06, C07D 417/10, C07D 233/88, C07D 413/04, C07D 401/12, C07D 271/113, C07D 249/14, C07D 285/08, C07D 417/14
US Classification:
544134, 548128, 5462687, 546209, 544367, 544316, 5462701, 548161, 5462694, 5462724, 548143, 5462714, 5462707, 5462754, 548138, 5462691, 5482648, 5483315
Abstract:
Provided are compounds of Formula I:or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, X, Z, Z, Z, Zand m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
Certain Chemical Entities, Compositions, And Methods
US Patent:
7989469, Aug 2, 2011
Filed:
Feb 2, 2009
Appl. No.:
12/364394
Inventors:
Zhe Yang - Daly City CA, US
Scott Collibee - San Carlos CA, US
Alex R. Muci - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jeff Gardina - Santa Clara CA, US
Brian Stoltz - San Marino CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Scott Collibee - San Carlos CA, US
Alex R. Muci - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jeff Gardina - Santa Clara CA, US
Brian Stoltz - San Marino CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Assignee:
Cytokinetics, Incorporated - South San Francisco CA
International Classification:
A61K 31/437, C07D 471/04, A61P 25/00
US Classification:
514303, 546118
Abstract:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
Certain Chemical Entities, Compositions And Methods
US Patent:
2011031, Dec 22, 2011
Filed:
Jun 21, 2011
Appl. No.:
13/165281
Inventors:
Zhe Yang - Daly City CA, US
Scott Collibee - San Carlos CA, US
Alex R. Muci - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jeff Gardina - Santa Clara CA, US
Brian Stoltz - San Marino CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Scott Collibee - San Carlos CA, US
Alex R. Muci - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jeff Gardina - Santa Clara CA, US
Brian Stoltz - San Marino CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
International Classification:
A61K 31/437, A61K 31/506, A61P 3/04, A61P 21/00, A61P 25/00, C07D 471/04, A61K 31/497
US Classification:
51425505, 546118, 514303, 544333, 514269, 544405
Abstract:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
Certain Chemical Entities, Compositions, And Methods
US Patent:
7851484, Dec 14, 2010
Filed:
Mar 28, 2008
Appl. No.:
12/058127
Inventors:
Bradley P. Morgan - Moraga CA, US
Gustave Bergnes - Pacifica CA, US
Alex Muci - San Francisco CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Marc Andrew Garard - Oakland CA, US
Gustave Bergnes - Pacifica CA, US
Alex Muci - San Francisco CA, US
Scott Collibee - San Carlos CA, US
Pu-Ping Lu - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Marc Andrew Garard - Oakland CA, US
Assignee:
Cytokinetics, Inc. - South San Francisco CA
International Classification:
A61K 31/444, C07D 471/02, A61P 21/00
US Classification:
514303, 546118
Abstract:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.
Certain Chemical Entities, Compositions, And Methods
US Patent:
2007016, Jul 12, 2007
Filed:
Nov 15, 2006
Appl. No.:
11/600684
Inventors:
Scott Collibee - San Carlos CA, US
Zhe Yang - Daly City CA, US
Luke Ashcraft - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Bradley Morgan - Moraga CA, US
David Morgans - Los Altos CA, US
Jianchao Wang - Foster City CA, US
Zhe Yang - Daly City CA, US
Luke Ashcraft - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Bradley Morgan - Moraga CA, US
David Morgans - Los Altos CA, US
Jianchao Wang - Foster City CA, US
International Classification:
A61K 31/454, C07D 401/02, C07D 211/32
US Classification:
514317000, 514326000, 546207000, 546225000
Abstract:
Compounds useful for treating cellular proliferative diseases are disclosed.
Imidazoyl-Benzamide Anti-Cancer Agents
US Patent:
7582668, Sep 1, 2009
Filed:
Nov 8, 2006
Appl. No.:
11/598250
Inventors:
Xiangping Qian - Foster City CA, US
Luke W. Ashcraft - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Bing Yao - Millbrae CA, US
Hong Jiang - Palo Alto CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Dashyant Dhanak - West Chester PA, US
Steven D. Knight - West Chester PA, US
Nicholas D. Adams - Royersford PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin J. Duffy - Philadelphia PA, US
Duke Fitch - Spring City PA, US
Rosanna Tedesco - Philadelphia PA, US
Luke W. Ashcraft - San Francisco CA, US
Jianchao Wang - Foster City CA, US
Bing Yao - Millbrae CA, US
Hong Jiang - Palo Alto CA, US
Gustave Bergnes - Pacifica CA, US
Bradley P. Morgan - Moraga CA, US
Dashyant Dhanak - West Chester PA, US
Steven D. Knight - West Chester PA, US
Nicholas D. Adams - Royersford PA, US
Cynthia A. Parrish - Philadelphia PA, US
Kevin J. Duffy - Philadelphia PA, US
Duke Fitch - Spring City PA, US
Rosanna Tedesco - Philadelphia PA, US
Assignee:
Cytokinetics, Incorporated - South San Francisco CA
SmithKline Beecham Corporation - Philadelphia PA
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/4178, C07D 403/10
US Classification:
514397, 5483147
Abstract:
Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
Luke Ashcraft
Location:
San Francisco Bay Area
Industry:
Research