Inventors:
The Johns Hopkins University - Baltimore MD, US
Julia B. Patrone - Ellicott City MD, US
Jason J. Benkoski - Ellicott City MD, US
Jennifer L. Breidenich - Atlanta MD, US
Lisa A. Kelly - Ellicott City MD, US
Le Huong - Olney MD, US
James C. Crookston - Falls Church VA, US
Marcia W. Patchan - Columbia MD, US
Luis Garza - Baltimore MD, US
Xiomara Calderon-Colon - Laurel MD, US
Joshua T. Wolfe - Bethesda MD, US
Mellisa L. Theodore - Nottingham MD, US
Amanda Nelson - Hummelstown PA, US
Sewon Kang - Phoenix MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 9/107, A61K 31/436, A61P 17/14, A61P 17/00, A61K 38/13, A61K 31/506, B82Y 5/00
US Classification:
424498, 424490, 514 207, 514291, 514275, 977773, 977906
Abstract:
A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.