LUIGI CUBEDDU, MD
Osteopathic Medicine at Bradenham Ln, Fort Lauderdale, FL
License number
Florida ME92341
Category
Osteopathic Medicine
Type
Hypertension Specialist
Address
Address
3468 Bradenham Ln, Fort Lauderdale, FL 33328
Phone
(954) 205-9359
Personal information
See more information about LUIGI CUBEDDU at radaris.comName
Address
Phone
2700 NE 15Th St, Ft Lauderdale, FL 33304
3468 Bradenham Ln, Davie, FL 33328
Fort Lauderdale, FL
3371 Lake Forest Dr, Fort Lauderdale, FL 33328
8325 Lake Forest Dr, Fort Lauderdale, FL 33328
Organization information
See more information about LUIGI CUBEDDU at bizstanding.comLuigi Cubeddu MD
Fort Lauderdale, FL - Hollywood, FL
Industry:
Medical Doctor's Office
Phone:
(954) 262-1354 (Phone)
Addresses:
3200 S University Dr, Fort Lauderdale, FL 33328
3200 S University Dr #1354, Davie, FL 33328
3200 S University Dr #1354, Davie, FL 33328
Owner:
Luigi Cubeddu (Owner)
Categories:
Physicians & Surgeons
Professional information
Luigi X Cubeddu
Specialties:
Cardiology
Languages:
English
Hospitals:
3468 Bradenham Ln, Fort Lauderdale 33328
Modulating Oncolytic Vsv And Upregulating Rae1 And Nup98 With Statins
US Patent:
2013030, Nov 14, 2013
Filed:
Nov 22, 2011
Appl. No.:
13/988768
Inventors:
Paula A. Faria-Waziry - Fort Lauderdale FL, US
Luigi X. Cubeddu - Fort Lauderdale FL, US
Ana Maria Castejon - Fort Lauderdale FL, US
Luigi X. Cubeddu - Fort Lauderdale FL, US
Ana Maria Castejon - Fort Lauderdale FL, US
Assignee:
NOVA SOUTHEASTERN UNIVERSITY - Fort Lauderdale FL
International Classification:
A61K 35/76, A61K 45/06, A61K 31/366
US Classification:
424 936
Abstract:
Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rae1 and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy.